Translational Medicine: Back to the Future

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2024-2025

Thematik

"You can be a good scientist without medicine, but you cannot be a good physician without science"

The biggest challenge of modern medicine is the separation of basic and clinical sciences from each other. In most cases the two fields do not understand each other. Consequently, in many cases there are lack of knowledge considering the onset of diseases, the pathomechanisms, also the shortcomings of prevention and our limited interventional, operative and pharmacological treatment options. Despite the excessive fundings of the development of pharmaceuticals, the number of drugs or new interventions used in clinical practise remains almost the same. Clinical research is far behind Basic Science in activity and clinical practice is in opposition to the latest findings of basic research in many countries. Considering all this, it is clear that succesful research is only possible through the co-operation of basic researchers and clinicians, which is Translational Medicine. The main role for Translational Medicine has to be the „interpreteur” for the two fields, by bringing their knowledge and research closer together.

One of the greatest advantages of this system is that the findings of basic research can be used in clinical practice almost immediately, therefore even in the short run the quality of health care can be increased.

This course is produced for those students who completed at least four semester. Who opt for this subject we kindly ask to take it into consideration.

Vorlesungen

• 1. Introduction to Translational Medicine: Three pillars of Translational Medicine; The interdisciplinary core facility in Translational Medicine - Hegyi Péter
• 2. Collection and use of clinical data; Clinical questions at the bedside (PICO) - Hegyi Péter
• 3. Clinical research methodology I: Meta-analyses I. - Hegyi Péter
• 4. Clinical research methodology I: Meta-analyses II. - Hegyi Péter
• 5. Clinical research methodology II: Database analysis - Hegyi Péter
• 6. Clinical research methodology III: Clinical trials I - Hegyi Péter
• 7. Clinical research methodology III: Clinical trials II - Hegyi Péter
• 8. Clinical research methodology IV: Retrospective data analyses, cross-sectional and cohort studies - Hegyi Péter
• 9. Clinical research methodology IV: Clinical pharmacological trials - Hegyi Péter
• 10. Assessment of the evidence (EBM, GRADE) - Hegyi Péter
• 11. Practicing EBM in the daily routine - Hegyi Péter

Praktika

• 1. Systematic literature search: electronic databases, search strategy - Hegyi Péter
• 2. Questions of meta-analyses: the PICO system - Hegyi Péter
• 3. Statistics I.: data types, the forest plot - Hegyi Péter
• 4. Statistics II.: heterogeneity and its causes; Risk of bias assessment; Evidence evaluation - Hegyi Péter
• 5. Operation of patient registries - Hegyi Péter
• 6. Observational clinical trials: analytical studies: cohort, case-control, cross-sectional studies; descriptive studies - Hegyi Péter
• 7. Intervention studies: randomization and blinding; types of interventions, selection of endpoints - Hegyi Péter
• 8. Statistics: sample size estimation, intention-to-treat and per-protocol analysis, subgroup analysis - Hegyi Péter
• 9. Distortions in observational and interventional clinical trials - Hegyi Péter
• 10. Implementation of the results in clinical practice and research planning - Hegyi Péter
• 11. Abstract, presentation, publication: When, what, for what purpose and for whom? - Hegyi Péter

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

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Vom Institut veröffentlichter Lehrstoff

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Skript

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Empfohlene Literatur

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Voraussetzung zum Absolvieren des Semesters

For successful completion at least 75% is required on the test.

Semesteranforderungen

At the end of the course students need to pass a written test-exam. For successful completion at least 75% is required.

Möglichkeiten zur Nachholung der Fehlzeiten

There is no possibility for replacement of absence.

Prüfungsfragen

Exam topics are based on lectures.

Prüfer

Praktika, Seminarleiter/innen

• Hegyi Péter