Pharmacopoeial Analysis 1. - Theory

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2019-2020

Thematik

Within the frame of the theoretical and practical trainings of this subject students will study the analytical approach of chemistry. This approach is crucial for the study of almost all pharmaceutical sciences like pharmaceutical chemistry, pharmaceutical technology etc. Students have to learn and examine the theory and practice of analytical reactions, methods, rules and calculations. Students will learn how to identify an unknown inorganic sample in both simple and complex manner of the analysis. At the end of the semester they should be able to know how to analyze an unknown sample for the most important cations and anions. Students should prove to demonstrate that they know how to use the theoretical knowledge in the pharmaceutical practice while finding out what their unknown sample is.

Vorlesungen

• 1. Definition, principles - Dr. Huber Imre
• 2. Topic of qualitative inorganic analysis - Dr. Huber Imre
• 3. Equilibrium reactions in solution - Dr. Huber Imre
• 4. Definition, calculations - Dr. Huber Imre
• 5. Classification of chemical reactions - Dr. Huber Imre
• 6. Electrode potentials - Dr. Huber Imre
• 7. Sensitivity and - Dr. Huber Imre
• 8. Specificity of a chemical reaction - Dr. Huber Imre
• 9. Classification of the cations - Dr. Huber Imre
• 10. 1st group of cations - Dr. Huber Imre
• 11. 2nd group of cations - Dr. Huber Imre
• 12. Separation of the first two groups - Dr. Huber Imre
• 13. 3rd group of cations I - Dr. Huber Imre
• 14. 3rd group of cations II - Dr. Huber Imre
• 15. 3rd group of cations III - Dr. Huber Imre
• 16. Separation of the 3rd group - Dr. Huber Imre
• 17. 4th group of cations - Dr. Huber Imre
• 18. 5th group of cations - Dr. Huber Imre
• 19. Classification of anions - Dr. Huber Imre
• 20. 1st anion group - Dr. Huber Imre
• 21. 2nd anion group I - Dr. Huber Imre
• 22. 2nd anion group I - Dr. Huber Imre
• 23. 3rd anion group - Dr. Huber Imre
• 24. 3rd anion group II - Dr. Huber Imre
• 25. 4th anion group I - Dr. Huber Imre
• 26. 4th anion group II - Dr. Huber Imre
• 27. Final written test - Dr. Huber Imre
• 28. Summary - Dr. Huber Imre

Praktika

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

A. Lásztity, J. Gyimesi: Qualitative Inorganic Analysis

Vom Institut veröffentlichter Lehrstoff

The students will receive lecture notes (SYLLABUS) from Dr Huber.

Skript

Empfohlene Literatur

1. P.W. West, M.M. Vieck, A.L. LeRosen: Qualitative Analysis and Analytical Chemical Separations
2. H F. Holtzclaw, W. R. Robinson: College Chemistry with Qualitative Analysis

Voraussetzung zum Absolvieren des Semesters

Maximum of 15 % absence allowed

Semesteranforderungen

Only those students are allowed to have exam at the and of the semester, who completed the practical course successfully.
The students will have to write two or three written midtermtests. None of them can be repeated, there is no retake. The result must be above 60%, respectively!!
Exam topics/questions
The semester is closed with a written test. In the case the result will not reach the 60% level, the student fails, she or he has to repeat the exam. In all other cases (above 60%), the student will receive a grade from qualitative inorganic analysis, based on the results of the two written tests and the overall result of the practical work throughout the semester (maximum score: 5 points).

Möglichkeiten zur Nachholung der Fehlzeiten

According to the regolations of the PTE.

Prüfungsfragen

1.) Definition, principles and topic of qualitative inorganic analysis. Quality assurance and control of chemical substances and active pharmaceutical ingredients. Available reactions. Stoichiometry.
2. Equilibrium reactions in solution, definition, calculations. Acid-base theories, calculation of pH, complexes (steric structures and isomerism), precipitate formation, solubility.
3.) Classification of chemical reactions: acid-base, complex-forming, and redox reactions. Electrode potentials.
4.) Sensitivity and specificity of chemical reactions. Dilution limit, limit-concentration. Analytical equipment, methods (macro, micro, semimicro, etc.). Preliminary investigations: sample-taking, homogenization, dissolution, digestion, direct heating, flame-test, etc.
5.) Classification of the cations: 1st group of cations (Ag+, Pb2+, Hg22+, Hg2+, Cu2+, Cd2+, Bi3+).
6.) 2nd group of cations (As3+, As5+, Sb3+, Sb5+, Sn2+, Sn4+. Separation of the first two groups of cations.
7.) 3rd group of cations I. (Co2+, Ni2+, Fe2+, Fe3+, Cr3+, Mn2+, Al3+, Zn2+).
8.) 3rd group of cations II. (Co2+, Ni2+, Fe2+, Fe3+, Cr3+, Mn2+, Al3+, Zn2+). Separation of the 3rd group of cations.
9.) 4th and 5th group of cations (Ca2+, Sr2+, Ba2+; Mg2+, Li+, Na+, K+, NH4+). Separation of the 4th and 5th group. Separation of magnesium ion from the other ions of the 5th group.
10.) Classification of the anions: 1st group of anions (CO32-, HCO3-, SO32-, S2O32-, S2- and Sx2-, SiO32-, OCl-).
11.) 2nd group of anions (IO3-, BrO3-, SO42-, PO43-, B(OH)4-, F-).
12.) 3rd group of anions (Cl-, Br-, I-, CN-, SCN-).
13.) 4th group of anions (NO2-, NO3-, ClO3-, ClO4-, CH3COO-). Complex analysis: cation(s) and anion(s) in the same sample. Practices

Prüfer

• Dr. Huber Imre

Praktika, Seminarleiter/innen