Physico-Chemical Bases of Drug Action

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2020-2021

Thematik

The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets for better understanding the drug action.

Vorlesungen

• 1. Molecular bases of biological actions. Structural characteristics of drug targets. - Dr. Rozmer Zsuzsanna
• 2. Molecular bases of biological actions. Structural characteristics of drug targets. - Dr. Rozmer Zsuzsanna
• 3. Receptors as drug targets. - Dr. Rozmer Zsuzsanna
• 4. Receptors as drug targets. - Dr. Rozmer Zsuzsanna
• 5. Enzymes as drug targets. - Dr. Rozmer Zsuzsanna
• 6. Enzymes as drug targets. - Dr. Rozmer Zsuzsanna
• 7. Transporters and ion channels as drug targets. - Dr. Rozmer Zsuzsanna
• 8. Transporters and ion channels as drug targets. - Dr. Rozmer Zsuzsanna
• 9. Nucleic acids as drug targets. - Dr. Rozmer Zsuzsanna
• 10. Nucleic acids as drug targets. - Dr. Rozmer Zsuzsanna
• 11. Physicochemical properties of drug-drug target interactions. Intermolecular bonding. - Dr. Rozmer Zsuzsanna
• 12. Physicochemical properties of drug-drug target interactions. Intermolecular bonding. - Dr. Rozmer Zsuzsanna
• 13. Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity. - Dr. Rozmer Zsuzsanna
• 14. Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity. - Dr. Rozmer Zsuzsanna
• 15. Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry. - Dr. Rozmer Zsuzsanna
• 16. Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry. - Dr. Rozmer Zsuzsanna
• 17. Physicochemical characteristics of drugs. Solubility. - Dr. Rozmer Zsuzsanna
• 18. Physicochemical characteristics of drugs. Solubility. - Dr. Rozmer Zsuzsanna
• 19. Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value. - Dr. Rozmer Zsuzsanna
• 20. Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value. - Dr. Rozmer Zsuzsanna
• 21. Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients. - Dr. Rozmer Zsuzsanna
• 22. Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients. - Dr. Rozmer Zsuzsanna
• 23. Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability. - Dr. Rozmer Zsuzsanna
• 24. Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability. - Dr. Rozmer Zsuzsanna
• 25. In silico ADME modelling. In vitro and in vivo tests. - Dr. Rozmer Zsuzsanna
• 26. In silico ADME modelling. In vitro and in vivo tests. - Dr. Rozmer Zsuzsanna
• 27. Physicochemical characteristics of drugs. Metabolic stability. - Dr. Rozmer Zsuzsanna
• 28. Physicochemical characteristics of drugs. Metabolic stability. - Dr. Rozmer Zsuzsanna

Praktika

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

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Vom Institut veröffentlichter Lehrstoff

Zsuzsanna Rozmer, Pál Perjési: The physico-chemeical bases of drug actions. PTE, 2015.

Skript

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Empfohlene Literatur

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Voraussetzung zum Absolvieren des Semesters

Maximum of 15 % absence allowed

Semesteranforderungen

Written test.

Möglichkeiten zur Nachholung der Fehlzeiten

None.

Prüfungsfragen

Topics of the written tests are set by the course director.

Prüfer

Praktika, Seminarleiter/innen

• Dr. Rozmer Zsuzsanna