Physico-Chemical Bases of Drug Action

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2024-2025

Thematik

The main objective of this course is to expand the knowledge in phyisico-chemical characterization of drug molecules and drug targets for better understanding the drug action.

Vorlesungen

• 1. Molecular bases of biological actions. Structural characteristics of drug targets. - Rozmer Zsuzsanna
• 2. Molecular bases of biological actions. Structural characteristics of drug targets. - Rozmer Zsuzsanna
• 3. Receptors as drug targets. - Rozmer Zsuzsanna
• 4. Receptors as drug targets. - Rozmer Zsuzsanna
• 5. Enzymes as drug targets. - Rozmer Zsuzsanna
• 6. Enzymes as drug targets. - Rozmer Zsuzsanna
• 7. Transporters and ion channels as drug targets. - Rozmer Zsuzsanna
• 8. Transporters and ion channels as drug targets. - Rozmer Zsuzsanna
• 9. Nucleic acids as drug targets. - Rozmer Zsuzsanna
• 10. Nucleic acids as drug targets. - Rozmer Zsuzsanna
• 11. Physicochemical properties of drug-drug target interactions. Intermolecular bonding. - Rozmer Zsuzsanna
• 12. Physicochemical properties of drug-drug target interactions. Intermolecular bonding. - Rozmer Zsuzsanna
• 13. Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity. - Rozmer Zsuzsanna
• 14. Physicochemical properties of drug-drug target interactions. Affinity. Efficiency and selectivity. - Rozmer Zsuzsanna
• 15. Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry. - Rozmer Zsuzsanna
• 16. Physicochemical properties of drug-drug target interactions. Stucture, stereochemistry. - Rozmer Zsuzsanna
• 17. Physicochemical characteristics of drugs. Solubility. - Rozmer Zsuzsanna
• 18. Physicochemical characteristics of drugs. Solubility. - Rozmer Zsuzsanna
• 19. Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value. - Rozmer Zsuzsanna
• 20. Physicochemical characteristics of drugs. Acid-base properties. Relevance and determination of the pKa value. - Rozmer Zsuzsanna
• 21. Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients. - Rozmer Zsuzsanna
• 22. Physicochemical characteristics of drugs. Lipophilicity and partition coefficient. Determination of partition coefficients. - Rozmer Zsuzsanna
• 23. Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability. - Rozmer Zsuzsanna
• 24. Physicochemical characteristics of drugs. Permeability. Experimental methods to determine permeability. - Rozmer Zsuzsanna
• 25. In silico ADME modelling. In vitro and in vivo tests. - Rozmer Zsuzsanna
• 26. In silico ADME modelling. In vitro and in vivo tests. - Rozmer Zsuzsanna
• 27. Physicochemical characteristics of drugs. Metabolic stability. - Rozmer Zsuzsanna
• 28. Physicochemical characteristics of drugs. Metabolic stability. - Rozmer Zsuzsanna

Praktika

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

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Vom Institut veröffentlichter Lehrstoff

PPT slides of the lectures

Skript

Zsuzsanna Rozmer, Pál Perjési: The physico-chemical bases of drug actions. PTE, 2015.

Empfohlene Literatur

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Voraussetzung zum Absolvieren des Semesters

Successful written exam.

Semesteranforderungen

Written test.

Möglichkeiten zur Nachholung der Fehlzeiten

None.

Prüfungsfragen

Topics of the written tests are set by the course director.

Prüfer

Praktika, Seminarleiter/innen

• Rozmer Zsuzsanna