Pharmaceutical Chemistry 4

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2024-2025

Thematik

Introduction to quality control of complex preparations. Application of instrumental methods in pharmacopoeal quality control of pharmaceutical preparations. Introduction of molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients.

Vorlesungen

• 1.

  Stability of drugs.

  - Tyukodi Levente
• 2.

  Stability of drugs.

  - Tyukodi Levente
• 3.

  Introduction to separation techniques.

  - Rozmer Zsuzsanna
• 4.

  Introduction to separation techniques.

  - Rozmer Zsuzsanna
• 5.

  Application of TLC in pharmaceutical analysis.

  - Tyukodi Levente
• 6.

  Application of TLC in pharmaceutical analysis.

  - Tyukodi Levente
• 7. Application of GC in pharmaceutical analysis. - Kulcsár Győző Kornél
• 8. Application of GC in pharmaceutical analysis. - Kulcsár Győző Kornél
• 9. Application of HPLC in pharmaceutical analysis. - Kulcsár Győző Kornél
• 10. Application of HPLC in pharmaceutical analysis. - Kulcsár Győző Kornél
• 11.

  Application of gel chromatography in pharmaceutical analysis.

  - Tyukodi Levente
• 12.

  Application of affinity chromatography in pharmaceutical analysis.

  - Tyukodi Levente
• 13. Vitamins. - Almási Attila
• 14. Vitamins. - Almási Attila
• 15. Antifungal drugs. Antiparasitic agents. - Kulcsár Győző Kornél
• 16. Antifungal drugs. Antiparasitic agents. - Kulcsár Győző Kornél
• 17. Antimicrobial agents. - Rozmer Zsuzsanna
• 18. Antimicrobial agents. - Rozmer Zsuzsanna
• 19. Antibiotics I. - Kovács-Rozmer Katalin
• 20. Antibiotics I. - Kovács-Rozmer Katalin
• 21. Antibiotics II. - Kovács-Rozmer Katalin
• 22. Antibiotics II. - Kovács-Rozmer Katalin
• 23. Anticancer agents. - Rozmer Zsuzsanna
• 24. Anticancer agents. - Rozmer Zsuzsanna
• 25. Antiviral agents. - Rozmer Zsuzsanna
• 26. Antiviral agents. - Rozmer Zsuzsanna
• 27.

  Drug research and drug development.

  - Rozmer Zsuzsanna
• 28.

  Drug research and drug development.

  - Rozmer Zsuzsanna

Praktika

• 1. Stability tests. Analysis of degradation of acetylsalicylic acid.
• ...

  2. Stability tests. Analysis of degradation of acetylsalicylic acid.

  3. Stability tests. Analysis of degradation of acetylsalicylic acid.
• 4. Stability tests. Analysis of degradation of acetylsalicylic acid.
• 5. Sample preparation. Extaction techniques. Liquid-liquid extraction of salycilic acid.
• ...

  6. Sample preparation. Extaction techniques. Liquid-liquid extraction of salycilic acid.

  7. Sample preparation. Extaction techniques. Liquid-liquid extraction of salycilic acid.
• 8. Sample preparation. Extaction techniques. Liquid-liquid extraction of salycilic acid.
• 9. Bases of chromatographic separations I. Detection of methanol in ethanol by TLC method. Separation of albumine and sodium chloride by gel chromatographic method.
• ...

  10. Bases of chromatographic separations I. Detection of methanol in ethanol by TLC method. Separation of albumine and sodium chloride by gel chromatographic method.

  11. Bases of chromatographic separations I. Detection of methanol in ethanol by TLC method. Separation of albumine and sodium chloride by gel chromatographic method.
• 12. Bases of chromatographic separations I. Detection of methanol in ethanol by TLC method. Separation of albumine and sodium chloride by gel chromatographic method.
• 13. Bases of chromatographic separations II. Application of gas chromatography in the analysis of pharmaceutical substances.
• ...

  14. Bases of chromatographic separations II. Application of gas chromatography in the analysis of pharmaceutical substances.

  15. Bases of chromatographic separations II. Application of gas chromatography in the analysis of pharmaceutical substances.
• 16. Bases of chromatographic separations II. Application of gas chromatography in the analysis of pharmaceutical substances.
• 17. Bases of chromatographic separations III. Application of the high performance liquid chromatography in the analysis of pharmaceutical substances.
• ...

  18. Bases of chromatographic separations III. Application of the high performance liquid chromatography in the analysis of pharmaceutical substances.

  19. Bases of chromatographic separations III. Application of the high performance liquid chromatography in the analysis of pharmaceutical substances.
• 20. Bases of chromatographic separations III. Application of the high performance liquid chromatography in the analysis of pharmaceutical substances.
• 21. Vitamines. Detremination of cyanocobalaminum by UV-Vis and HPLC methods.
• ...

  22. Vitamines. Detremination of cyanocobalaminum by UV-Vis and HPLC methods.

  23. Vitamines. Detremination of cyanocobalaminum by UV-Vis and HPLC methods.
• 24. Vitamines. Detremination of cyanocobalaminum by UV-Vis and HPLC methods.
• 25. Identification of multi-component drug mixtures I. General principles. Sample preparation. Determination of bases in drug mixtures I. Pulvis antispasticus.
• ...

  26. Identification of multi-component drug mixtures I. General principles. Sample preparation. Determination of bases in drug mixtures I. Pulvis antispasticus.

  27. Identification of multi-component drug mixtures I. General principles. Sample preparation. Determination of bases in drug mixtures I. Pulvis antispasticus.
• 28. Identification of multi-component drug mixtures I. General principles. Sample preparation. Determination of bases in drug mixtures I. Pulvis antispasticus.
• 29. Identification of multi-component drug mixtures II. Determination of bases in drug mixtures II. Pulvis antidoloricus. Pulvis astmaliticus. Pulvis codacetini. Application of HPLC.
• ...

  30. Identification of multi-component drug mixtures II. Determination of bases in drug mixtures II. Pulvis antidoloricus. Pulvis astmaliticus. Pulvis codacetini. Application of HPLC.

  31. Identification of multi-component drug mixtures II. Determination of bases in drug mixtures II. Pulvis antidoloricus. Pulvis astmaliticus. Pulvis codacetini. Application of HPLC.
• 32. Identification of multi-component drug mixtures II. Determination of bases in drug mixtures II. Pulvis antidoloricus. Pulvis astmaliticus. Pulvis codacetini. Application of HPLC.
• 33. Identification of multi-component drug mixtures III. Determination of bases in drug mixtures III. Pulvis cholagogus, Unguentum haemorrhoidale, Suppositorium analgeticum.
• ...

  34. Identification of multi-component drug mixtures III. Determination of bases in drug mixtures III. Pulvis cholagogus, Unguentum haemorrhoidale, Suppositorium analgeticum.

  35. Identification of multi-component drug mixtures III. Determination of bases in drug mixtures III. Pulvis cholagogus, Unguentum haemorrhoidale, Suppositorium analgeticum.
• 36. Identification of multi-component drug mixtures III. Determination of bases in drug mixtures III. Pulvis cholagogus, Unguentum haemorrhoidale, Suppositorium analgeticum.
• 37. Identification of multi-component drug mixtures IV. Determination of acids in drug mixtures I. Spiritus iodosalicylatus, Spiritus salicylatus cum resorcino.
• ...

  38. Identification of multi-component drug mixtures IV. Determination of acids in drug mixtures I. Spiritus iodosalicylatus, Spiritus salicylatus cum resorcino.

  39. Identification of multi-component drug mixtures IV. Determination of acids in drug mixtures I. Spiritus iodosalicylatus, Spiritus salicylatus cum resorcino.
• 40. Identification of multi-component drug mixtures IV. Determination of acids in drug mixtures I. Spiritus iodosalicylatus, Spiritus salicylatus cum resorcino.
• 41. Identification of multi-component drug mixtures V. Determination of acids in drug mixtures II. Pulvis chinacisalis c. vitamino C, Pulvis somniferens.
• ...

  42. Identification of multi-component drug mixtures V. Determination of acids in drug mixtures II. Pulvis chinacisalis c. vitamino C, Pulvis somniferens.

  43. Identification of multi-component drug mixtures V. Determination of acids in drug mixtures II. Pulvis chinacisalis c. vitamino C, Pulvis somniferens.
• 44. Identification of multi-component drug mixtures V. Determination of acids in drug mixtures II. Pulvis chinacisalis c. vitamino C, Pulvis somniferens.
• 45. Drug metabolism (seminary).
• ...

  46. Drug metabolism (seminary).

  47. Drug metabolism (seminary).
• 48. Drug metabolism (seminary).
• 49. In vitro and in vivo methods in the drug metabolism studies. Acetylsalicylic acid, 4-nitrophenol.
• ...

  50. In vitro and in vivo methods in the drug metabolism studies. Acetylsalicylic acid, 4-nitrophenol.

  51. In vitro and in vivo methods in the drug metabolism studies. Acetylsalicylic acid, 4-nitrophenol.
• 52. In vitro and in vivo methods in the drug metabolism studies. Acetylsalicylic acid, 4-nitrophenol.
• 53. Chemical and structural classification of functional groups and heterocycles. (seminary).
• ...

  54. Chemical and structural classification of functional groups and heterocycles. (seminary).

  55. Chemical and structural classification of functional groups and heterocycles. (seminary).
• 56. Chemical and structural classification of functional groups and heterocycles. (seminary).

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

D.A. Williams, T.L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins, Philadelphia, 2013

Vom Institut veröffentlichter Lehrstoff

Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic educational material, PTE 2014

Skript

Pharmaceutical Chemistry Practice 1, Laboratory manual, University of Pécs, 2015

Empfohlene Literatur

European Pharmacopoeia. EDQM Publication

Lecture notes

Voraussetzung zum Absolvieren des Semesters

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Students have to write two midterm tests (week 7. and 12.) from the topics of the theory and the practice. One of the test result should be at least 60%, and the average of the test result should be at least 50%. Students can have one retake per midterm test. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Semesteranforderungen

Students have to write two midterm tests (week 7. and 12.) from the topics of the theory and the practice. One of the test result should be at least 60%, and the average of the test result should be at least 50%. Students can have one retake per midterm test. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Möglichkeiten zur Nachholung der Fehlzeiten

There is no opportunity to make up missed classes.

Prüfungsfragen

Oral exam covering the topics of Pharmaceutical Chemistry I-IV. Before the exam each student should have a Minimum Requirement Test of which result should be at least 80%.

Further details: www.gytk.pte.hu

Prüfer

• Rozmer Zsuzsanna

Praktika, Seminarleiter/innen

• Harmath Lilla Édua
• Rozmer Zsuzsanna
• Tyukodi Levente