Synthesis of Heterocyclic Compounds and Their Application in Therapy

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2025-2026

Thematik

Heterocyclic chemistry is an important subdivision of organic chemistry, as 70% of all medicines are heterocyclic compound or contains a heterocyclic moiety. This course will give an introduction to, and the summary of, the most important principles and ideas of heterocyclic chemistry. This course partially re-calls the knowledge of Organic chemisty 1 and Organic chemistry 2 course, discusses those details which were not reflected on, because of time shortage and supports to evaluate the pharmacological chemistry subject.

-Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds, Saturated heterocycles, occurence of heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurence)

-The pyrrole and indole (synthesis, reactions, occurence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms: imidazole, oxazole, thiazole

-Pyrazole, isoxazole, isothiazole

-I. st test, Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines, triazines etc.)

-Seven membered heterocyclic chemistry

-Heterocycles in supramolecular chemitry

-Heterocyclic compounds in organic snthesis

-II nd test, short presntation on a paper on heterocyclic chemistry

-Evaluation

Vorlesungen

Praktika

Seminare

• 1. Electronic structure of heterocycles, nomenclature of heterocycles - Kálai Tamás
• 2. Occurence of heterocyclic compounds - Kálai Tamás
• 3. Synthesis of heterocycles - Kálai Tamás
• 4. Common reaction types in heterocyclic chemistry - Kálai Tamás
• 5. Tautomerism in heterocyclic chemistry - Kálai Tamás
• 6. Saturated heterocycles - Kálai Tamás
• 7. Three and four membered heterocycles, beta lactams - Kálai Tamás
• 8. Three and four-membered heterocycles and beta lactams - Kálai Tamás
• 9. Synthesis of pyrroles and porfirine ring containing compounds - Kálai Tamás
• 10. Synthesis of indoles, main reactions of indoles. - Kálai Tamás
• 11. Furans and thiophenes - Kálai Tamás
• 12. Thiophenes and benzothiophenes - Kálai Tamás
• 13. 1,2-azoles, their synthesis, reactions and their occurence in drugs - Kálai Tamás
• 14. 1,3-azoles, their synthesis, reactions, occurence in drugs - Kálai Tamás
• 15. 1st test (generral feature of heterocyclic compounds (3-, 4-, 5-membered heterocycles) - Kálai Tamás
• 16. Six membered heterocycles containing oxygen heteroatom - Kálai Tamás
• 17. Pyridines (synthesis, reactions, occurence in drugs and biomolecules) - Kálai Tamás
• 18. Quinolines, isoquinolines (synthesis, reactions, occurence in drugs) - Kálai Tamás
• 19. Synthesis of pyrimidines and their occurence in medicines - Kálai Tamás
• 20. Synthesis and reactions of 1,2- and 1,4-diazines - Kálai Tamás
• 21. Synthesis and reactions of triazines and purines - Kálai Tamás
• 22. Heterocycles of life and death - Kálai Tamás
• 23. Seven membered heterocycles their occurence, synthesis, applications in therapy - Kálai Tamás
• 24. IInd test, short presentations on papers on heterocyclic chemistry, evaluation - Kálai Tamás
• 25. Heterocycles in supramolecular chemistry - Kálai Tamás
• 26. Heterocycles in organic synthesis - Kálai Tamás
• 27. 2nd test (6- and 7-membered heterocycles) - Kálai Tamás
• 28. Short presentations, evaluations - Kálai Tamás

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

Li, J. J. Hetrocyclic chemistry in Drug Discovery, Wiley

Vom Institut veröffentlichter Lehrstoff

Slides will be given to students as a ppt or pdf files.

Skript

Joule, J. J.; Mills, K. Heterocyclic chemistry at a Glance. (Wiley)

Empfohlene Literatur

Li, J. J. Top 10 drugs Oxfors University Press

Voraussetzung zum Absolvieren des Semesters

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Semesteranforderungen

The students write two tests, at the middle of the semester and at the end of the semester. Every student have a chance to make a presentation based on a heterocyclic chemistry paper for an extra grade.

Möglichkeiten zur Nachholung der Fehlzeiten

Personal communication. The english program student might visit the paralell hungarian course to catch up the main reaction equations.

Prüfungsfragen

-Electronic structure of heterocycles

-Nomenclature of heterocyclic compounds

-Main synthetic routes to heterocyclic compounds

-Saturated heterocycles

-Three and four membered heterocycles (synthesis, reactions, occurence)

-The pyrrole and indole (synthesis, reactions, occurence)

-Furan, thiophene and their benzo derivatives.

-Five membered heterocycles with two or more heteroatoms

-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)

-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)

-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)

-Seven membered heterocyclic chemistry

- Heterocycles in supramolecular chemitry

-Heterocyclic compounds in organic snthesis

Prüfer

Praktika, Seminarleiter/innen

• Kálai Tamás