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Epigenetics - The Missing Link in Understanding Pathogeneses?

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2019-2020

Lehrbeauftragte/r

Semesterwochenstunden

Vorlesungen: 12

Praktika: 0

Seminare: 0

Insgesamt: 12

Fachangaben

  • Kode des Kurses: OAF-MLP-T
  • 1 kredit
  • General Medicine
  • Optional modul
  • autumn
Voraussetzungen:

keine

Zahl der Kursteilnehmer für den Kurs:

min. 1 – max. 50

Erreichbar als Campus-Kurs für 1 fő számára. Campus-karok: ÁOK TTK

Thematik

Why are certain family members affected by tumorous diseases and others are not? Can the lifestyles of our grandparents and parents affect our health? What kind of molecular factors and mechanisms might be involved in epigenetics, including transgenerational inheritance? Is epigenetics the missing link between genetics, the environment and disease? These fundamental questions will be addressed and the latest advances of the field will be discussed. Moreover, epigenetic biomarkers and therapeutic potential of epigenetic drugs (epigenetic enzyme inhibitors) will be also covered.

Vorlesungen

  • 1. Milestones of epigenetics - from Conrad Waddington to David Allis - Dr. Rauch Tibor Attila
  • 2. DNA methylation and demethylation – the first discovered epigenetic alterations - Dr. Rauch Tibor Attila
  • 3. Histone protein-related epigenetic signals - Dr. Rauch Tibor Attila
  • 4. Non-coding RNAs (miRNA, piRNA and lncRNA) in cell biology and pathogeneses - Dr. Rauch Tibor Attila
  • 5. Epigenetic methods, including single-locus and genome-wide analysis tools - Dr. Rauch Tibor Attila
  • 6. Genetic imprinting and X chromosome inactivation - Dr. Rauch Tibor Attila
  • 7. Stem cell and differentiation-associated epigenetic events - Dr. Rauch Tibor Attila
  • 8. Epigenetics of cancer - Dr. Rauch Tibor Attila
  • 9. Epigenetics of autoimmune diseases - Dr. Rauch Tibor Attila
  • 10. Epigenetic aspects of memory and neurological disorders - Dr. Rauch Tibor Attila
  • 11. Epigenetic biomarkers and therapeutic interventions - Dr. Rauch Tibor Attila
  • 12. Exam (oral or written) - Dr. Rauch Tibor Attila

Praktika

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

-

Vom Institut veröffentlichter Lehrstoff

PowerPoint presentation according to lectures

Skript

-

Empfohlene Literatur

Handbook of Epigenetics, 2nd Edition, Editors: Trygve Tollefsbol, eBook ISBN: 9780128054772, Hardcover ISBN: 9780128053881, Academic Press, Published Date: 7th August 2017

Voraussetzung zum Absolvieren des Semesters

Maximum of 15 % absence allowed

Semesteranforderungen

Closing test

Möglichkeiten zur Nachholung der Fehlzeiten

None

Prüfungsfragen

1. Milestones of epigenetics
2. DNA methylation and demethylation
3. Histone protein-related epigenetic signals
4. Non-coding RNAs
5. Epigenetic methods
6. Genetic imprinting
7. Stem cell and differentiation-associated epigenetic events
8. Epigenetics of cancer
9. Epigenetics of autoimmune diseases
10. Epigenetic aspects of memory and neurological disorders
11. Epigenetic biomarkers and therapeutic interventions
12. X-chromosome inactivation

Prüfer

Praktika, Seminarleiter/innen

Rólunk