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Epigenetics - The Missing Link in Understanding Pathogeneses?

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2024-2025

Lehrbeauftragte/r

  • Rauch Tibor Attila

    senior research fellow,
    Department of Medical Biology and Central Electron Microscope Laboratory

Semesterwochenstunden

Vorlesungen: 12

Praktika: 0

Seminare: 0

Insgesamt: 12

Fachangaben

  • Kode des Kurses: OAF-MLP-T
  • 1 kredit
  • General Medicine
  • Optional modul
  • autumn
Voraussetzungen:

keine

Zahl der Kursteilnehmer für den Kurs:

min. 5 – max. 15

Erreichbar als Campus-Kurs für . Campus-karok: ÁOK GYTK TTK

Thematik

Why can one member of a family develop a tumor and not the other? Can the lifestyle of our parents and grandparents affect our health? What molecular factors and mechanisms may be responsible for the inheritance of acquired traits? Is epigenetics the missing link between genetics, environment and disease? The course will focus primarily on these questions and will present the most commonly used epigenetic techniques.

Vorlesungen

  • 1. Milestones of epigenetics - from Conrad Waddington to David Allis - Rauch Tibor Attila
  • 2. DNA methylation and demethylation - the first discovered epigenetic alterations - Rauch Tibor Attila
  • 3. Histone protein-related epigenetic signals - Rauch Tibor Attila
  • 4. Non-coding RNAs (miRNA, piRNA and lncRNA) in cell biology and pathogeneses - Rauch Tibor Attila
  • 5. Epigenetic methods, including single-locus and genome-wide analysis tools - Rauch Tibor Attila
  • 6. Genetic imprinting and X chromosome inactivation - Rauch Tibor Attila
  • 7. Stem cell and differentiation-associated epigenetic events - Rauch Tibor Attila
  • 8. Epigenetics of cancer - Rauch Tibor Attila
  • 9. Epigenetics of autoimmune diseases - Rauch Tibor Attila
  • 10. Epigenetic aspects of memory and neurological disorders - Rauch Tibor Attila
  • 11. Epigenetic biomarkers and therapeutic interventions - Rauch Tibor Attila
  • 12. Exam (oral or written) - Rauch Tibor Attila

Praktika

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

-

Vom Institut veröffentlichter Lehrstoff

PowerPoint presentation according to lectures

Skript

-

Empfohlene Literatur

Handbook of Epigenetics, 2nd Edition, Editors: Trygve Tollefsbol, eBook ISBN: 9780128054772, Hardcover ISBN: 9780128053881, Academic Press, Published Date: 7th August 2017

Voraussetzung zum Absolvieren des Semesters

None

Semesteranforderungen

Closing test

Möglichkeiten zur Nachholung der Fehlzeiten

None

Prüfungsfragen

1. Milestones of epigenetics

2. DNA methylation and demethylation

3. Histone protein-related epigenetic signals

4. Non-coding RNAs

5. Epigenetic methods

6. Genetic imprinting

7. Stem cell and differentiation-associated epigenetic events

8. Epigenetics of cancer

9. Epigenetics of autoimmune diseases

10. Epigenetic aspects of memory and neurological disorders

11. Epigenetic biomarkers and therapeutic interventions

12. X-chromosome inactivation

Prüfer

Praktika, Seminarleiter/innen

Rólunk