Genomics and Epigenomics in Development and Disease

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2023-2024

Thematik

Epigenetics is the study of heritable changes in phenotype that do not involve alterations in the genome. Environmental effects or normal developmental programs can result in epigenetic changes. During the course, an international team (University of Birmingham, UK, University of Pecs, Hungary) will explain both in a lecture format and in a practical session the fundamentals of epigenetics.
In the first part of the course, the concept of genomics, genome structure, and techniques of genome data harvesting is established, then the principles and levels of gene regulation, the concept of epigenetic gene regulation, as a paradigm are highlighted, and integrated into the network-based approach of genetic regulation. In further lectures, the general principles of animal development, and developmental genetic and genomics-based studies will be presented in the evolutionary developmental biology (EVO-DEVO) context, and medical aspects considered.

Vorlesungen

• 1. Vertebrate genomics, introduction - Müller Ferenc
• 2. Epigenetic means of gene regulation. Histone postranslational modifications, histone code - Müller Ferenc
• 3. Mechanisms of epigenetic inheritance, intra and intergenerational inheritance - Müller Ferenc
• 4. Non-coding genome function, gene regulation mechanisms. Cis regulatory elements, chromatin function and structure - Müller Ferenc
• 5. Enhancers promoter structure function and interactions - Müller Ferenc
• 6. Genomics applications in medical research - Müller Ferenc
• 7. Stem cells, regeneration and epigenetical aspects of human development, medical implications - Dr. Hoffmann Gyula
• 8. Evolutionary genomics, genetic background for special characteristics of animals - Dr. Hoffmann Gyula
• 9. How to use and mine genomics data in a Genome browser (UCSC) - Müller Ferenc
• 10. How to use and mine genomics data in a Genome browser (UCSC) - Müller Ferenc

Praktika

• 1. Sequencing 1
• 2. Sequencing 2

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

Vom Institut veröffentlichter Lehrstoff

Lecture materials by the teachers and their publications on this topic

Skript

Empfohlene Literatur

Voraussetzung zum Absolvieren des Semesters

Maximum of 15 % absence allowed

Semesteranforderungen

No mid-semester tests. Essay.

Möglichkeiten zur Nachholung der Fehlzeiten

After 3 missed classes the semester signature is automatically denied, there is no possibility to make up for the missed classes.

Prüfungsfragen

A submitted 2500-word long essay (the student will have the choice of one title out of an offer of 3-5 titles proposed, and the essay will be written, in English, by the student over a period of two weeks, and submitted for marking by academic staff).

Prüfer

Praktika, Seminarleiter/innen