Data
Official data in SubjectManager for the following academic year: 2023-2024
Course director
-
Dr. Attila Gábor SIK
senior research fellow,
Institute of Transdisciplinary Discoveries - Director of Innovation, Institute of Physiology -
Number of hours/semester
lectures: 10 hours
practices: 2 hours
seminars: 0 hours
total of: 12 hours
Subject data
- Code of subject: OBF-EGD-T
- 1 kredit
- Biotechnology MSc
- Optional modul
- autumn
OBA-132-T completed
Course headcount limitations
min. 5 – max. 20
Available as Campus course for 20 fő számára. Campus-karok: ÁOK ETK GYTK TTK
Topic
Epigenetics is the study of heritable changes in phenotype that do not involve alterations in the genome. Environmental effects or normal developmental programs can result in epigenetic changes. During the course, an international team (University of Birmingham, UK, University of Pecs, Hungary) will explain both in a lecture format and in a practical session the fundamentals of epigenetics.
In the first part of the course, the concept of genomics, genome structure, and techniques of genome data harvesting is established, then the principles and levels of gene regulation, the concept of epigenetic gene regulation, as a paradigm are highlighted, and integrated into the network-based approach of genetic regulation. In further lectures, the general principles of animal development, and developmental genetic and genomics-based studies will be presented in the evolutionary developmental biology (EVO-DEVO) context, and medical aspects considered.
Lectures
- 1. Vertebrate genomics, introduction - Müller Ferenc
- 2. Epigenetic means of gene regulation. Histone postranslational modifications, histone code - Müller Ferenc
- 3. Mechanisms of epigenetic inheritance, intra and intergenerational inheritance - Müller Ferenc
- 4. Non-coding genome function, gene regulation mechanisms. Cis regulatory elements, chromatin function and structure - Müller Ferenc
- 5. Enhancers promoter structure function and interactions - Müller Ferenc
- 6. Genomics applications in medical research - Müller Ferenc
- 7. Stem cells, regeneration and epigenetical aspects of human development, medical implications - Dr. Hoffmann Gyula
- 8. Evolutionary genomics, genetic background for special characteristics of animals - Dr. Hoffmann Gyula
- 9. How to use and mine genomics data in a Genome browser (UCSC) - Müller Ferenc
- 10. How to use and mine genomics data in a Genome browser (UCSC) - Müller Ferenc
Practices
- 1. Sequencing 1
- 2. Sequencing 2
Seminars
Reading material
Obligatory literature
Literature developed by the Department
Lecture materials by the teachers and their publications on this topic
Notes
Recommended literature
Conditions for acceptance of the semester
Maximum of 15 % absence allowed
Mid-term exams
No mid-semester tests. Essay.
Making up for missed classes
After 3 missed classes the semester signature is automatically denied, there is no possibility to make up for the missed classes.
Exam topics/questions
A submitted 2500-word long essay (the student will have the choice of one title out of an offer of 3-5 titles proposed, and the essay will be written, in English, by the student over a period of two weeks, and submitted for marking by academic staff).