Clinical Laboratory Investigations

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

Clinical Laboratory Investigations is a subject based on a solid knowledge in chemistry, biochemistry and (patho)physiology. It gives a practical guide to understand and interpret a wide variety of modern laboratory tests by showing the molecular basis of them. The subject includes classic (bio)chemical methods, immunochemistry, hematology, blood coagulation, toxicology and molecular biology. The major methodological aspects and applications are discussed during the lectures. The aim of the subject is to give pharmaceutical students a practical knowledge whereby they could reliably interpret basic clinical laboratory results in their routine pratice.

Lectures

• 1. Clinical Biochemistry: analysis of samples obtained from the human body and interpretation of test results. - Horváth-Szalai Zoltán
• 2. Different factors influencing the results of lab tests. Informational value of test results (reference intervals, statistical approaches). - Horváth-Szalai Zoltán
• 3. Different laboratory approaches in water and electrolyte disorders. - Szirmay Balázs Gábor
• 4. Acid-base balance. Methods and interpretation of test results. - Szirmay Balázs Gábor
• 5. Analysis of plasma proteins. - Horváth-Szalai Zoltán
• 6. Analysis of plasma proteins. - Horváth-Szalai Zoltán
• 7.

  Calcium, magnesium and bone metabolism. Laboratory findings in bone diseases.

  - Kőszegi Tamás Antal
• 8.

  Analysis of plasma enzymes including isoenzymes. How enzymes get into the extracellular space?
  

  - Horváth-Szalai Zoltán
• 9. Carbohydrate metabolism and significance of related laboratory tests. - Vassné Lakatos Ágnes
• 10. Carbohydrate metabolism and significance of related laboratory tests. - Vassné Lakatos Ágnes
• 11. Basic principles of blood coagulation and hematological analyses. - Réger Barbara
• 12. Basic principles of blood coagulation and hematological analyses. - Réger Barbara
• 13.

  Midterm I.

  - Kőszegi Tamás Antal
• 14.

  Iron, porphyrin and hemoglobin metabolism.

  - Kőszegi Tamás Antal
• 15. Automated immunochemical measurements. - Kőszegi Tamás Antal
• 16.

  Different approaches in liver and gastrointestinal diseases.

  - Kőszegi Tamás Antal
• 17.

  Tumors and tumor markers.

  - Kőszegi Tamás Antal
• 18.

  Disorders of lipid metabolism.

  - Szirmay Balázs Gábor
• 19.

  Muscle diseases and analysis of the endocrine system.

  - Kőszegi Tamás Antal
• 20.

  Muscle diseases and analysis of the endocrine system.

  - Kőszegi Tamás Antal
• 21.

  Laboratory investigation of kidney diseases.

  - Szirmay Balázs Gábor
• 22.

  Therapeutic drug monitoring (TDM) in the clinical laboratory.

  - Vassné Lakatos Ágnes
• 23.

  Midterm II.

  - Szirmay Balázs Gábor
• 24.

  Midterm II.

  - Szirmay Balázs Gábor

Practices

Seminars

Reading material

Obligatory literature

There is no obligatory handbook

Literature developed by the Department

All lectures are accessible at Neptun Meet Street and in Teams in pdf form

Notes

There is no official lecture notes book

Recommended literature

W.J. Marshall, M. Lapsley, A. Day, K. Shipman : Clinical Chemistry, 9th ed., Elsevier, 2020, ISBN 9780702079368

P. Rae, M. Crane, R. Pattenden: Lecture Notes on Clinical Biochemistry, 10th ed., Wiley-Blackwell Co., 2017. ISBN: 978-1-119-24868-2

M.J. Murphy, R. Srivastava, K. Deans: Clinical Biochemistry, An Illustrated Colour Text, 6th ed., Elsevier 2018. ISBN: 0702072982

Conditions for acceptance of the semester

.

Mid-term exams

One midterm multiple choice is due in October-November

A second midterm multiple choice is due in December

The final grade (mark) is given by evaluation of the combined results of the two midterms

Making up for missed classes

An absence rate of less than 25% is acceptable, no medical or other certificate is necessary.

Exam topics/questions

In every semester new multiple choice questions are given.

Examiners

Instructor / tutor of practices and seminars