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Education

Pathophysiology of Blood Cells

Data

Official data in SubjectManager for the following academic year: 2024-2025

Course director

Number of hours/semester

lectures: 12 hours

practices: 0 hours

seminars: 0 hours

total of: 12 hours

Subject data

  • Code of subject: OAF-VAE-T
  • 1 kredit
  • General Medicine
  • Optional modul
  • spring
Prerequisites:

OAP-KN1-T finished

Course headcount limitations

min. 5 – max. 100

Topic

The course focuses on the pathophysiology of erythropoiesis and on the structural and functional abnormalities of blood cells at a preclinical level. In addition to those of red blood cells, functions and disorders of leukocytes and platelets are discussed. Related functional and clinical conditions together with the pathophysiological basis of possible therapies will also be included. Theory is complemented by case histories.

Lectures

  • 1. The functions of blood. Erythropoiesis, leukopoiesis, thrombopoiesis. Case histories. - Balaskó Márta
  • 2. Polycythemia vera and spuria: etiology, pathogenesis and complications. - Balaskó Márta
  • 3. Morphology of red blood cells, corpuscular hemolytic anemias. - Balaskó Márta
  • 4. Sickle cell anemia: etiology, pathogenesis, pathophysiology of therapeutic possibilities. - Balaskó Márta
  • 5. Thalassemias: etiology, complications, treatment. Case histories. - Balaskó Márta
  • 6. Extracorpuscular hemolytic anemias. Case histories. - Balaskó Márta
  • 7. Abnormalities of the neutrophil granulocytes. Case histories. - Balaskó Márta
  • 8. Abnormalities of eosinophil and basophil granulocytes. - Balaskó Márta
  • 9. Abnormalities of lymphocytes. Case studies. - Balaskó Márta
  • 10. Platelets: structure, functions and related pathophysiology. - Balaskó Márta
  • 11. Pathophysiological significance of endothel cells. Case histories. - Balaskó Márta
  • 12. Test. Case histories. - Balaskó Márta

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Lecture slides are uploaded to Teams.

Notes

Recommended literature

Hoffbrand, Moss and Pettit: Essential Haematology, 5th edition, Blackwell 2006 ISBN 1-4051-3649-9

Székely Miklós (editor) Basic concepts in pathopysiology. Medicina Publishing House Budapest, 2019.

Conditions for acceptance of the semester

None

Mid-term exams

None

Making up for missed classes

An essay on the topic of the missed lecture.

Exam topics/questions

The functions of blood. Erythropoiesis, leukopoiesis, thrombopoiesis.

Polycythemia vera and spuria: etiology, pathogenesis and complications.

Morphology of red blood cells, corpuscular hemolytic anemias.

Sickle cell anemia: etiology, pathogenesis, pathophysiology of therapeutic possibilities.

Thalassemias: etiology, complications, treatment. Case histories.

Extracorpuscular hemolytic anemias.

Abnormalities of the neutrophil granulocytes.

Abnormalities of eosinophil and basophil granulocytes.

Abnormalities of lymphocytes.

Platelets: structure, functions and related pathophysiology.

Pathophysiological significance of endothel cells.

The grade depends on the result of the final test.

Examiners

Instructor / tutor of practices and seminars

Rólunk