Mechanisms of Cancer Metastasis

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

Metastasis is the primary cause of cancer related mortality, however, molecular mechanisms remain poorly understood. The invading tumor cells interact with macromolecules and other cells locally in the tumor microenvironment as well as while disseminating. Plasticity and survival of metastatic cancer cells is mediated by these interactions. Revealing the molecular mechanisms of the complex metastatic process is crucial for development of novel efficient therapeutic approaches. Students attending the class will learn about recent findings in the field of metastasis research. Novel in vitro models and their challenges are discussed in details.

Lectures

• 1. Overview of the metastatic cascade - Juhász Kata
• 2. Strategies of cancer cell invasion - Balogi Zsolt
• 3. Cancer stem cells - Juhász Kata
• 4. Metastasis-associated oncoproteomics - Balogi Zsolt
• 5. Anti invasion/metastasis drugs - Balogi Zsolt
• 6. Tumor Microenvironment: A Biomechanically Aberrant Tissue - Juhász Kata
• 7. Tumor-Associated Macrophages - Juhász Kata
• 8. Intravasation, circulating cancer cells, immune system in metastasis - Juhász Kata
• 9. In Vitro Modeling of Cancer Metastasis - Balogi Zsolt
• 10. Dormancy and reactivation of cancer cells - Juhász Kata
• 11. Mouse models of metastasis - Balogi Zsolt
• 12. Consultation - Juhász Kata

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

power point slides of the lectures

Notes

Recommended literature

scientific papers listed on power point slides of the lectures

Conditions for acceptance of the semester

-

Mid-term exams

Brief report (600 words) of 2 recent research articles based on defined aspects

Making up for missed classes

additional written report on the topic missed by the student

Exam topics/questions

-

Examiners

Instructor / tutor of practices and seminars