Mechanisms of Cancer Metastasis

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2024-2025

Tematika

Metastasis is the primary cause of cancer related mortality, however, molecular mechanisms remain poorly understood. The invading tumor cells interact with macromolecules and other cells locally in the tumor microenvironment as well as while disseminating. Plasticity and survival of metastatic cancer cells is mediated by these interactions. Revealing the molecular mechanisms of the complex metastatic process is crucial for development of novel efficient therapeutic approaches. Students attending the class will learn about recent findings in the field of metastasis research. Novel in vitro models and their challenges are discussed in details.

Előadások

• 1. Overview of the metastatic cascade - Juhász Kata
• 2. Strategies of cancer cell invasion - Balogi Zsolt
• 3. Cancer stem cells - Juhász Kata
• 4. Metastasis-associated oncoproteomics - Balogi Zsolt
• 5. Anti invasion/metastasis drugs - Balogi Zsolt
• 6. Tumor Microenvironment: A Biomechanically Aberrant Tissue - Juhász Kata
• 7. Tumor-Associated Macrophages - Juhász Kata
• 8. Intravasation, circulating cancer cells, immune system in metastasis - Juhász Kata
• 9. In Vitro Modeling of Cancer Metastasis - Balogi Zsolt
• 10. Dormancy and reactivation of cancer cells - Juhász Kata
• 11. Mouse models of metastasis - Balogi Zsolt
• 12. Consultation - Juhász Kata

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

power point slides of the lectures

Jegyzet

Ajánlott irodalom

scientific papers listed on power point slides of the lectures

A félév elfogadásának feltételei

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Félévközi ellenőrzések

Brief report (600 words) of 2 recent research articles based on defined aspects

Távolmaradás pótlásának lehetőségei

additional written report on the topic missed by the student

Vizsgakérdések

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Vizsgáztatók

Gyakorlatok, szemináriumok oktatói