Great Discoveries in Pharmacology

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The aim of the lectures is to show how and through what discoveries pharmaceutical science came to today's modern age. Thanks to the famous scientists presented their achieved breakthroughs in their own age have fundamentally changed scientific thinking. Pharmacology has a rich and long-standing heritage, which today completed with new disciplines such as molecular biology and genetics, which provide powerful tools for study pharmacodynamics and pharmacokinetics. During the semester, students will gain insight into the pharmacological methods in those ages when researchers achieved their world-famous discoveries without today’s sophisticated tools.

Lectures

• 1. Important principles of drug treatments: Sir James Black, Gertrude Elion és és Geroge Hitchins. - Hartnerné Pohóczky Krisztina
• 2. Discoveries of János Kabay. - Hartnerné Pohóczky Krisztina
• 3. The discovery of penicillin and its curative effects in various infectious diseases: Sir Alexander Fleming, Cecil Paine, Harold Raistrick, Ernst Chain, and Sir Howard Florey. - Hartnerné Pohóczky Krisztina
• 4. The scientific impact of Antal Bayer. - Hartnerné Pohóczky Krisztina
• 5. The roles of prostaglandins and related biologically active substances: Sune Bergstrom, Bengt Samuelsson, and John Vane. - Hartnerné Pohóczky Krisztina
• 6. Richter Gedeon and the kalmopyrin. - Hartnerné Pohóczky Krisztina
• 7. Discovery of cyclic AMP and protein phosphorylation as a key mechanism in the regulation of cellular function: Earl W. Sutherland, Edwin G. Krebs and Edmond H. Fischer. - Hartnerné Pohóczky Krisztina
• 8. Career and research of Albert Szent-Györgyi. - Hartnerné Pohóczky Krisztina
• 9. G proteins and their role in signal transduction: Rodbell and Alfred G. Gilman. - Hartnerné Pohóczky Krisztina
• 10. Life and researh of Louis Pasteur. - Hartnerné Pohóczky Krisztina
• 11. The history of chemotherapy: from the chemical weapons to Sydney Farber. - Szőke Éva
• 12. History of capsaicin research, discovery of capsaicin-sensitive sensory nerve endings and their role: Miklós Jancsó and János Szolcsányi. - Szőke Éva
• 13. Nitric oxide as a signaling molecule of the cardiovascular system: Robert Furchgott, Ferid Murad és Louis Ignarro. - Hartnerné Pohóczky Krisztina
• 14. József Béres; inventor and scientist. - Hartnerné Pohóczky Krisztina

Practices

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Own educational material will be available in digital form in the Neptun Meet Street.

Notes

Recommended literature

Ronald P. Rubin: A brief history of great discoveries in pharmacology: in celebration of the centennial anniversary of the founding of the american society of pharmacology and experimental therapeutics, 2007: Pharmacological Reviews 59: 289-359.

Conditions for acceptance of the semester

-

Mid-term exams

During the semester, each student have to give a short presentation on a chosen topic related to drug discovery.

Making up for missed classes

There is no possibility to make up the lectures.

Exam topics/questions

The final mark will based on the short oral presentation of a famous discovery or famous researcher.

Examiners

Instructor / tutor of practices and seminars