Data
Official data in SubjectManager for the following academic year: 2024-2025
Course director
-
Pethő Gábor István
professor,
-
Number of hours/semester
lectures: 28 hours
practices: 0 hours
seminars: 0 hours
total of: 28 hours
Subject data
- Code of subject: OBI-009-E
- 2 kredit
- Biotechnology MSc
- Specialty in Pharmaceutical Biotechnology modul
- autumn
OBI-008-E finished
Course headcount limitations
min. 1 – max. 30
Topic
Molecular toxicology as a subject deals with the toxic (including teratogenic and carcinogenic) effects of drugs and xenobiotics caused by overdose or excessive exposure. It describes the general aspects of toxicology, the mechanisms of toxicity (including the major influencing factors), the harmful effects, and certain aspects of the treatment options. In addition, toxicity testing will be also discussed.
Lectures
- 1.
Introduction of toxicology.
- Hartnerné Pohóczky Krisztina - 2.
The principles of toxicodynamics.
- Hartnerné Pohóczky Krisztina - 3.
The principles of toxicokinetics I.
- Hartnerné Pohóczky Krisztina - 4.
The principles of toxicokinetics II.
- Hartnerné Pohóczky Krisztina - 5.
The principles of toxicokinetics III.
- Hartnerné Pohóczky Krisztina - 6.
The principles of toxicokinetics IV.
- Hartnerné Pohóczky Krisztina - 7.
Toxic effects caused by biological mimicri I.
- Hartnerné Pohóczky Krisztina - 8.
Toxic effects caused by biological mimicri II.
- Hartnerné Pohóczky Krisztina - 9.
Disruption of cellular energy production I.
- Hartnerné Pohóczky Krisztina - 10.
Disruption of cellular energy production II.
- Hartnerné Pohóczky Krisztina - 11.
Disruption of cell homeostasis and/or physiology I.
- Hartnerné Pohóczky Krisztina - 12.
Disruption of cell homeostasis and/or physiology II.
- Hartnerné Pohóczky Krisztina - 13.
Summary and consultation I.
- Hartnerné Pohóczky Krisztina - 14.
Summary and consultation II.
- Hartnerné Pohóczky Krisztina - 15.
Xenobiotics causing tissue injury or tissue necrosis
- Hartnerné Pohóczky Krisztina - 16.
Xenobiotics causing CNS toxicity
- Hartnerné Pohóczky Krisztina - 17.
Oxidative damage and adduct formation I.
- Hartnerné Pohóczky Krisztina - 18.
Oxidative damage and adduct formation II.
- Hartnerné Pohóczky Krisztina - 19.
Chemical carcinogenesis I.
- Hartnerné Pohóczky Krisztina - 20.
Chemical carcinogenesis II.
- Hartnerné Pohóczky Krisztina - 21.
Chemical teratogenesis I.
- Hartnerné Pohóczky Krisztina - 22.
Chemical teratogenesis II.
- Hartnerné Pohóczky Krisztina - 23.
Toxicity testing I.
- Hartnerné Pohóczky Krisztina - 24.
Toxicity testing II.
- Hartnerné Pohóczky Krisztina - 25.
Toxicity testing III.
- Hartnerné Pohóczky Krisztina - 26.
Toxicity testing IV.
- Hartnerné Pohóczky Krisztina - 27.
Summary and consultation III.
- Hartnerné Pohóczky Krisztina - 28.
Summary and consultation IV.
- Hartnerné Pohóczky Krisztina
Practices
Seminars
Reading material
Obligatory literature
Literature developed by the Department
Slides of each lecture will be available for the students on Neptun Meet Street.
Notes
Recommended literature
C.D. Klassen (ed.): Casarett & Doull's Toxicology. The Basic Science of Poisons. 9th edition, McGraww-Hill, 2019.
Conditions for acceptance of the semester
-
Mid-term exams
Students are required to take two mid-semester written tests, which are scheduled for weeks 7 and 13, approximately. These tests will contain multiple choice and short essay type questions. The average score of these two mid-semester tests (%) will be evaluated. We will offer a final grade for those reaching a mid-term result of at least 50%.
Making up for missed classes
Missed classes cannot be made up.
Exam topics/questions
The exam includes each topic discussed during the lectures and presented in lecture slides (available in Neptun Meet Street). Those have not achieved at least 50% in mid-term tests have to take a written exam during the exam period.
Examiners
- Hartnerné Pohóczky Krisztina