Pharmacodynamics 1

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the field of pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics, pharmacology of the autonomic nervous system and the cardiovascular system. It must be emphasized that the knowledge of the physiological principles is absolutely needed for the study of this subject.

Lectures

• 1. Introduction to neuropharmacology. General characterization of the autonomic nervous system - Barthó Loránd
• 2. Cholinergic agonists - Barthó Loránd
• 3. Cholinesterase inhibitors I - Barthó Loránd
• 4. Cholinesterase inhibitors II - Barthó Loránd
• 5. Muscarinic receptor antagonists I - Barthó Loránd
• 6. Muscarinic receptor antagonists II - Barthó Loránd
• 7. Neuromuscular blocking agents I - Pethő Gábor István
• 8. Neuromuscular blocking agents II - Pethő Gábor István
• 9. Agents acting on biosynthesis, storage, release and elimination of catecholamines I - Pethő Gábor István
• 10. Agents acting on biosynthesis, storage, release and elimination of catecholamines II - Pethő Gábor István
• 11. Adrenergic receptor agonists I - Barthó Loránd
• 12. Adrenergic receptor agonists II - Barthó Loránd
• 13. Adrenergic receptor antagonists I - Barthó Loránd
• 14. Adrenergic receptor antagonists II - Barthó Loránd
• 15. Pharmacology of calcium channels I - Pethő Gábor István
• 16. Pharmacology of calcium channels II - Pethő Gábor István
• 17. Drugs acting on the renin-angiotensin-aldosterone system I - Poór Miklós
• 18. Drugs acting on the renin-angiotensin-aldosterone system II - Poór Miklós
• 19. Diuretics I - Pethő Gábor István
• 20. Diuretics II - Pethő Gábor István
• 21. Drugs used to treat congestive heart failure I - Börzsei Rita Judit
• 22. Drugs used to treat congestive heart failure II - Börzsei Rita Judit
• 23. Antiarrhythmic drugs I - Pethő Gábor István
• 24. Antiarrhythmic drugs II - Pethő Gábor István
• 25. Antianginal drugs I - Pethő Gábor István
• 26. Antianginal drugs II. Drugs that increase regional blood flow - Pethő Gábor István
• 27. Antihypertensive drugs I - Pethő Gábor István
• 28. Antihypertensive drugs II - Pethő Gábor István

Practices

Seminars

• 1. Introduction to pharmacodynamics I - Pethő Gábor István
• 2. Introduction to pharmacodynamics II - Pethő Gábor István
• 3. Basic mechanisms of drug actions - Faisal Anna Zelma
• 4. Characterization of agonist-receptor interaction I - Faisal Anna Zelma
• 5. Characterization of agonist-receptor interaction II - Faisal Anna Zelma
• 6. Characterization of agonist-receptor interaction III - Faisal Anna Zelma
• 7. Signal transduction mechanisms of drug receptors - Mohos Violetta Karolin
• 8. Tachyphylaxis and tolerance to drugs - Mohos Violetta Karolin
• 9. Mechanisms of drug antagonisms I - Mohos Violetta Karolin
• 10. Mechanisms of drug antagonisms II - Mohos Violetta Karolin
• 11. Transport of drugs across membranes - Fliszár-Nyúl Eszter
• 12. Absorption of drugs I - Fliszár-Nyúl Eszter
• 13. Absorption of drugs II. Binding of drugs to plasma proteins - Poór Miklós
• 14. Distribution of drugs - Poór Miklós
• 15. Biotransformation of drugs I - Poór Miklós
• 16. Biotransformation of drugs II - Poór Miklós
• 17. Biotransformation of drugs III - Poór Miklós
• 18. Excretion of drugs - Poór Miklós
• 19. Pharmacokinetic parameters I - Fliszár-Nyúl Eszter
• 20. Pharmacokinetic parameters II - Fliszár-Nyúl Eszter
• 21. Local anesthetics I - Pethő Gábor István
• 22. Local anesthetics II - Pethő Gábor István
• 23. Drugs acting on autonomic ganglia - Pethő Gábor István
• 24. Theoretical basis of the effects of drugs acting on the autonomic nervous system - Pethő Gábor István
• 25. Discussion of the pharmacology of the parasympathetic nervous system I. - Barthó Loránd
• 26. Discussion of the pharmacology of the parasympathetic nervous system II - Barthó Loránd
• 27. Discussion of the pharmacology of the sympathetic nervous system I - Barthó Loránd
• 28. Discussion of the pharmacology of the sympathetic nervous system II - Barthó Loránd

Reading material

Obligatory literature

Literature developed by the Department

Electronic handouts are provided for most topics.

Notes

Recommended literature

Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2019

B. G. Katzung (ed.): Basic and Clinical Pharmacology, 14th edition, Lange Medical Books/McGraw-Hill, 2018

Conditions for acceptance of the semester

None.

Mid-term exams

After the 10th week of the semester, a midterm test is written. The test covers the material of the seminars of the first 10 weeks of the semester. Students are required to reach at least 50%. Should someone fail to reach 50%, the semester performance will not be accepted and the student cannot take the exam. In such a case, students not reaching the required 50% on the first midterm test will have the possibility to repeat the written test until the end of the semester. In case of a final failure (that is after the improvement attempt), the student cannot take the exam.

Making up for missed classes

There is no way to make up for missed lectures or seminars.

Exam topics/questions

Reqirements: the exams are oral, the required topics are dealt with in lectures and seminars.

Exam questions:

1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects mediated by physicochemical interactions)

2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy

3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs

4. Mechanisms of drug antagonisms

5. Transport of drugs across membranes

6. Absorption of drugs

7. Distribution of drugs

8. Biotransformation of drugs

9. Excretion of drugs

10. Quantitative pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability, calculation of loading and maintenance doses

11. Cholinergic agonists and cholinesterase inhibitors

12. Muscarinic receptor antagonists

13. Neuromuscular blocking agents. Drugs acting on autonomic ganglia

14. Agents acting on the biosynthesis, storage, release and elimination of catecholamines

15. Adrenergic receptor agonists

16. Adrenergic receptor antagonists

17. Local anaesthetics

18. Calcium channel blockers

19. Drugs acting on the renin-angiotensin-aldosterone system

20. Diuretic drugs

21. Positive inotropic and other drugs used to treat congestive heart failure

22. Antianginal drugs. Drugs that increase regional blood flow

23. Antihypertensive drugs

24. Antiarrhythmic drugs

In addition to the exam topics, an important part of the exam is answering questions that aim at assessing the general knowledge of the student.

Examiners

• Barthó Loránd
• Pethő Gábor István
• Poór Miklós

Instructor / tutor of practices and seminars

• Faisal Anna Zelma
• Fliszár-Nyúl Eszter
• Mohos Violetta Karolin
• Pethő Gábor István
• Poór Miklós