Pharmacodynamics 1 - Practice

Data

Official data in SubjectManager for the following academic year: 2024-2025

Topic

The aim of the course is to provide the students with the pharmacological knowledge required for their future work in the field of pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics.

Lectures

Practices

• 1.

  Introduction to pharmacodynamics I

  - Pethő Gábor István
• 2.

  Introduction to pharmacodynamics II

  - Pethő Gábor István
• 3.

  Basic mechanisms of drug actions

  - Fliszár-Nyúl Eszter
• 4.

  Characterization of the agonist-receptor interaction I

  - Fliszár-Nyúl Eszter
• 5.

  Characterization of the agonist-receptor interaction II

  - Fliszár-Nyúl Eszter
• 6.

  Characterization of the agonist-receptor interaction III

  - Fliszár-Nyúl Eszter
• 7. Signal transduction mechanisms of drug receptors - Hartnerné Pohóczky Krisztina
• 8. Tachyphylaxis and tolerance - Hartnerné Pohóczky Krisztina
• 9.

  Mechanisms of drug antagonisms I

  - Hartnerné Pohóczky Krisztina
• 10.

  Mechanisms of drug antagonisms II

  - Hartnerné Pohóczky Krisztina
• 11.

  Transport of drugs across membranes

  - Dombi Ágnes
• 12.

  Absorption of drugs I

  - Kriszta Gábor
• 13.

  Absorption of drugs II

  - Kriszta Gábor
• 14.

  Distribution of drugs

  - Kriszta Gábor
• 15.

  Biotransformation of drugs I

  - Fliszár-Nyúl Eszter
• 16.

  Biotransformation of drugs II

  - Fliszár-Nyúl Eszter
• 17.

  Excretion of drugs I

  - Pozsgai Gábor
• 18.

  Excretion of drugs II

  - Pozsgai Gábor
• 19.

  Pharmacokinetic parameters I

  - Dombi Ágnes
• 20.

  Pharmacokinetic parameters II

  - Dombi Ágnes
• 21.

  Pharmacokinetic parameters III

  - Dombi Ágnes
• 22.

  Local anesthetics I

  - Pethő Gábor István
• 23.

  Local anesthetics II

  - Pethő Gábor István
• 24.

  Theoretical basis of the modulation of the pharmacology of the autonomic nervous system. Drugs acting on autonomic ganglia

  - Pethő Gábor István
• 25.

  Analysis of the effects of drugs acting on the autonomic nervous system using computer simulation I

  - Barthó Loránd
• 26.

  Analysis of the effects of drugs acting on the autonomic nervous system using computer simulation II

  - Barthó Loránd
• 27.

  Discussion of the pharmacology of the autonomic nervous system I

  - Pozsgai Gábor
• 28.

  Discussion of the pharmacology of the autonomic nervous system II

  - Pozsgai Gábor

Seminars

Reading material

Obligatory literature

Literature developed by the Department

Electronic handouts are provided for most topics.

Notes

Recommended literature

Rang, Dale, Ritter, Moore: Pharmacology, 9th edition, Elsevier Churchill Livingstone, 2019

B. G. Katzung (ed.): Basic and Clinical Pharmacology, 15th edition, Lange Medical Books/McGraw-Hill, 2021

Conditions for acceptance of the semester

None.

Mid-term exams

The students receive a practice grade based on their performance during the semester. The grade will be registered in the Neptun as a midsemester grade. The grade must be at least satisfactory as a prerequisite for taking the semester exam. Around the 11th week of the semester, a written test is the base of the practice grade. The test covers the subjects of practice classes of the first 10 weeks of the semester and 50% of the available points must be reached for acceptance of the semester. Should someone fail or want to improve, they can do it one time before the end of the semester. On a final failure (that is, after the improvement attempt still below 50%), the student cannot have semester accepted.

Making up for missed classes

There is no way to make up for missed classes.

Exam topics/questions

1. Basic mechanisms of drug actions

2. Characterization of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy

3. Significance of signal transduction mechanisms in the effects of drugs. Tachyphylaxis and tolerance to drugs

4. Mechanisms of drug antagonisms

5. Transport of drugs across membranes

6. Absorption of drugs, oral bioavailability and presystemic elimination

7. Distribution of drugs

8. Biotransformation of drugs

9. Excretion of drugs

10. Quantitative pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability, calculation of loading and maintenance doses, non-linear pharmacokinetics

Examiners

Instructor / tutor of practices and seminars

• Barthó Loránd
• Dombi Ágnes
• Fliszár-Nyúl Eszter
• Hartnerné Pohóczky Krisztina
• Kriszta Gábor
• Pethő Gábor István
• Pozsgai Gábor