Pharmaceutical Chemistry 3

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2022-2023

Tematika

Introduction to the most important instrumental analytical methods and their applications to pharmacopoeal qualification of active pharmaceutical ingredients and experiments. Introduction to molecular aspect and structure-activity relationship of selected group of active pharmaceutical ingredients.

Előadások

• 1. Application of CD and ORD spectroscopy in pharmaceutical analysis. - Dr. Rozmer Zsuzsanna
• 2. Application of UV-Vis spectroscopy in pharmaceutical analysis - Dr. Perjési Pál
• 3. Application of UV-Vis spectroscopy in pharmaceutical analysis. - Dr. Perjési Pál
• 4. Application of thermoanalytic methods in pharmaceutical analysis. - Dr. Kulcsár Győző Kornél
• 5. Application of fluorimetry in pharmaceutical analysis. - Dr. Perjési Pál
• 6. Application of fluorimetry in pharmaceutical analysis. - Dr. Perjési Pál
• 7. Application of atomic absorption spectrometry and flame photometry in pharmaceutical analysis. - Dr. Kulcsár Győző Kornél
• 8. Application of IR spectroscopy in pharmaceutical analysis. - Dr. Perjési Pál
• 9. Application of IR spectroscopy in pharmaceutical analysis. - Dr. Perjési Pál
• 10. Biological drugs I. - Dr. Rozmer Zsuzsanna
• 11. Application of NMR spectroscopy in pharmaceutical analysis. - Dr. Perjési Pál
• 12. Application of NMR spectroscopy in pharmaceutical analysis. - Dr. Perjési Pál
• 13. Biological drugs II. - Dr. Rozmer Zsuzsanna
• 14. Application of mass spectrometry in pharmaceutical analysis. - Dr. Kulcsár Győző Kornél
• 15. Application of mass spectrometry in pharmaceutical analysis. - Dr. Kulcsár Győző Kornél
• 16. Antiallergic antihistamines. Drugs for rheumatic gout I. - Dr. Rozmer Zsuzsanna
• 17. Application of electroanalytical methods in pharmaceutical analysis. - Dr. Perjési Pál
• 18. Application of electroanalytical methods in pharmaceutical analysis. - Dr. Perjési Pál
• 19. Antiallegic antihistamines. Drugs for rheumatic gout II. - Dr. Rozmer Zsuzsanna
• 20. Agents of cardiac failure. - Dr. Rozmer Zsuzsanna
• 21. Agents of cardiac failure. - Dr. Rozmer Zsuzsanna
• 22. Antianginal drugs. - Dr. Rozmer Zsuzsanna
• 23. Agents of antiarythmic agents. - Dr. Almási Attila
• 24. Agents of antiarythmic agents. - Dr. Almási Attila
• 25. Antithrombotics, Thrombolytics, Coagulants I. - Dr. Rozmer Zsuzsanna
• 26. Antihipertensive agents. - Dr. Almási Attila
• 27. Antihipertensive agents. - Dr. Almási Attila
• 28. Antithrombotics, Thrombolytics, Coagulants II. - Dr. Rozmer Zsuzsanna
• 29. Antihiperlidemic agents. - Dr. Rozmer Zsuzsanna
• 30. Antihiperlidemic agents. - Dr. Rozmer Zsuzsanna
• 31. Drugs affecting thyroid functions. - Dr. Almási Attila
• 32. Diuretics. - Dr. Almási Attila
• 33. Diuretics. - Dr. Almási Attila
• 34. Adrenocorticoids I. - Dr. Perjési Pál
• 35. Drugs affecting calcium homeostatis. - Dr. Rozmer Zsuzsanna
• 36. Drugs affecting calcium homeostatis. - Dr. Rozmer Zsuzsanna
• 37. Adrenocorticoids II. - Dr. Perjési Pál
• 38. Insulin and oral hypoglycemic drugs. - Dr. Almási Attila
• 39. Insulin and oral hypoglycemic drugs. - Dr. Almási Attila
• 40. Estrogens, Androgens, Progestins I. - Dr. Perjési Pál
• 41. Estrogens, Androgens, Progestins II. - Dr. Perjési Pál
• 42. Estrogens, Androgens, Progestins II. - Dr. Perjési Pál

Gyakorlatok

• 1. Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I. Identification of 10 inorganic and organic substances I.
• 2. Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I. Identification of 10 inorganic and organic substances I.
• 3. Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I. Identification of 10 inorganic and organic substances I.
• 4. Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I. Identification of 10 inorganic and organic substances I.
• 5. Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic substances II.
• 6. Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic substances II.
• 7. Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic substances II.
• 8. Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic substances II.
• 9. Principles of validation of analytical methods. (Seminars)
• 10. Principles of validation of analytical methods. (Seminars)
• 11. Principles of validation of analytical methods. (Seminars)
• 12. Principles of validation of analytical methods. (Seminars)
• 13. Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according to the Ph. Hg. VII. and the Ph. Hg. VIII.
• 14. Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according to the Ph. Hg. VII. and the Ph. Hg. VIII.
• 15. Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according to the Ph. Hg. VII. and the Ph. Hg. VIII.
• 16. Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according to the Ph. Hg. VII. and the Ph. Hg. VIII.
• 17. Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of coffein, aminophenazone and paracetamol in powder mixtures.
• 18. Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of coffein, aminophenazone and paracetamol in powder mixtures.
• 19. Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of coffein, aminophenazone and paracetamol in powder mixtures.
• 20. Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of coffein, aminophenazone and paracetamol in powder mixtures.
• 21. Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric methods.
• 22. Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric methods.
• 23. Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric methods.
• 24. Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric methods.
• 25. Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)
• 26. Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)
• 27. Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)
• 28. Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)
• 29. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug substances. (Seminar) Application of mass spectrometry methods.
• 30. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug substances. (Seminar) Application of mass spectrometry methods.
• 31. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug substances. (Seminar) Application of mass spectrometry methods.
• 32. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug substances. (Seminar) Application of mass spectrometry methods.
• 33. Application of electroanalytical methods in pharmaceutical analysis. (Seminar)
• 34. Application of electroanalytical methods in pharmaceutical analysis. (Seminar)
• 35. Application of electroanalytical methods in pharmaceutical analysis. (Seminar)
• 36. Application of electroanalytical methods in pharmaceutical analysis. (Seminar)
• 37. Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a weak acid in mixtures.
• 38. Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a weak acid in mixtures.
• 39. Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a weak acid in mixtures.
• 40. Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a weak acid in mixtures.
• 41. Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by direct potentiometric titration.
• 42. Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by direct potentiometric titration.
• 43. Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by direct potentiometric titration.
• 44. Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by direct potentiometric titration.
• 45. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.
• 46. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.
• 47. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.
• 48. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.
• 49. Pharmacopoeial analysis of steroidal hormons.
• 50. Pharmacopoeial analysis of steroidal hormons.
• 51. Pharmacopoeial analysis of steroidal hormons.
• 52. Pharmacopoeial analysis of steroidal hormons.
• 53. Basics of stereochemistry. Stereochemistry of steroids and derivatives.
• 54. Basics of stereochemistry. Stereochemistry of steroids and derivatives.
• 55. Basics of stereochemistry. Stereochemistry of steroids and derivatives.
• 56. Basics of stereochemistry. Stereochemistry of steroids and derivatives.

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

D.A. Williams, T.L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins, Philadelphia, 2013

Saját oktatási anyag

Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic educational material, PTE 2014

Jegyzet

Pharmaceutical Chemistry Practice 1, laboratory manual, University of Pécs, 2015

Ajánlott irodalom

European Pharmacopoeia, EDQM Publication
Lecture notes

A félév elfogadásának feltételei

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the practices is obligatory. Maximum three absences can be accepted both from lectures and practices. There is an obligation to write two midterm tests (week 7. and 12.) from the topics of the theory and the practice. One of the test results should be above 60%, the average of the tests sholuld be above 50%. One re-take test is allowed at the 14th weak of the semester. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Félévközi ellenőrzések

If the student did not take part writing the midterm test, she or he can participate the retake, only. There is no chance for extra possibilities.

Távolmaradás pótlásának lehetőségei

There is no opportunity to make up missed classes.

Vizsgakérdések

Written exam covering the topics of the lectures and the laboratory practices. The result of the written exam must be above 60%. The final grade is based on results of the midterm tests and the written exam. Maximum contribution of the results of the midterm tests to the total score of the written exam is 25%. Participation on the first exam is compulsory.

Vizsgáztatók

• Dr. Perjési Pál
• Dr. Rozmer Zsuzsanna

Gyakorlatok, szemináriumok oktatói

• Dr. Almási Attila
• Dr. Rozmer Zsuzsanna
• Dr. Tyukodi Levente