Pharmaceutical Chemistry 3 - Practice

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2022-2023

Tematika

Introduction to the most important instrumental analytical methods and their applications to pharmacopoeal qualification of active pharmaceutical ingredients and excipients in pharamaceutical formulations.

Előadások

Gyakorlatok

• 1. Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I. Identification of 10 inorganic and organic substances I.
• 2. Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I. Identification of 10 inorganic and organic substances I.
• 3. Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I. Identification of 10 inorganic and organic substances I.
• 4. Laboratory safety and accident protection. Preliminary testing and classification of inorganic and organic compounds I. Identification of 10 inorganic and organic substances I.
• 5. Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic substances II.
• 6. Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic substances II.
• 7. Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic substances II.
• 8. Preliminary testing and classification of inorganic and organic compounds II. Identification of 10 inorganic and organic substances II.
• 9. Principles of validation of analytical methods. (Seminars)
• 10. Principles of validation of analytical methods. (Seminars)
• 11. Principles of validation of analytical methods. (Seminars)
• 12. Principles of validation of analytical methods. (Seminars)
• 13. Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according to the Ph. Hg. VII. and the Ph. Hg. VIII.
• 14. Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according to the Ph. Hg. VII. and the Ph. Hg. VIII.
• 15. Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according to the Ph. Hg. VII. and the Ph. Hg. VIII.
• 16. Validation of a titrimetric methods. Comparison of different methods, Determination of sodium hydrogen carbonate according to the Ph. Hg. VII. and the Ph. Hg. VIII.
• 17. Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of coffein, aminophenazone and paracetamol in powder mixtures.
• 18. Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of coffein, aminophenazone and paracetamol in powder mixtures.
• 19. Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of coffein, aminophenazone and paracetamol in powder mixtures.
• 20. Spectrophotometry I. The Lambert-Beer's law. Determination of specific absorbance. Spectrophotometric determination of coffein, aminophenazone and paracetamol in powder mixtures.
• 21. Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric methods.
• 22. Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric methods.
• 23. Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric methods.
• 24. Spectrophotometry II. Determination of salicylic acid and acetylsalicylic acid in mixtures by spectrophotometric and alkalimetric methods.
• 25. Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)
• 26. Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)
• 27. Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)
• 28. Application of fluometric methods. Application of NMR in pharmaceutical analysis. Principles of evaluation of NMR spectra. Evaluation of 1H and 13C NMR spectra of selected drug substances. (Seminar)
• 29. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug substances. (Seminar) Application of mass spectrometry methods.
• 30. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug substances. (Seminar) Application of mass spectrometry methods.
• 31. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug substances. (Seminar) Application of mass spectrometry methods.
• 32. Application of IR in pharmaceutical analysis. Principles of evaluation of IR spectra. Evaluation of IR spectra of selected drug substances. (Seminar) Application of mass spectrometry methods.
• 33. Application of electroanalytical methods in pharmaceutical analysis. (Seminar)
• 34. Application of electroanalytical methods in pharmaceutical analysis. (Seminar)
• 35. Application of electroanalytical methods in pharmaceutical analysis. (Seminar)
• 36. Application of electroanalytical methods in pharmaceutical analysis. (Seminar)
• 37. Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a weak acid in mixtures.
• 38. Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a weak acid in mixtures.
• 39. Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a weak acid in mixtures.
• 40. Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Determination of a strong and a weak acid in mixtures.
• 41. Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by direct potentiometric titration.
• 42. Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by direct potentiometric titration.
• 43. Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by direct potentiometric titration.
• 44. Potentiometry II. Electrodes used in potentiometry. Definition and importance of the pKa value. Determination of the pKa by direct potentiometric titration.
• 45. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.
• 46. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.
• 47. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.
• 48. Spectrophotometry III. Determination of the pKa of a weak acid and a weak base by spectrophotometry.
• 49. Pharmacopoeial analysis of steroidal hormons.
• 50. Pharmacopoeial analysis of steroidal hormons.
• 51. Pharmacopoeial analysis of steroidal hormons.
• 52. Pharmacopoeial analysis of steroidal hormons.
• 53. Basics of stereochemistry. Stereochemistry of steroids and derivatives.
• 54. Basics of stereochemistry. Stereochemistry of steroids and derivatives.
• 55. Basics of stereochemistry. Stereochemistry of steroids and derivatives.
• 56. Basics of stereochemistry. Stereochemistry of steroids and derivatives.

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

D.A. Williams, T.L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins, Philadelphia, 2013

Saját oktatási anyag

Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry 1. Laboratory Experiments and Commentary, electronic educational material, PTE 2014

Jegyzet

Pharmaceutical Chemistry Practice 1, laboratory manual, University of Pécs, 2015

Ajánlott irodalom

European Pharmacopoeia, EDQM Publication
Lecture notes.

A félév elfogadásának feltételei

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory. Maximum three absences can be accepted. Students have to write at least four short tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Félévközi ellenőrzések

Students have to write at least four short tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Távolmaradás pótlásának lehetőségei

There is no opportunity to make up missed classes.

Vizsgakérdések

The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói

• Dr. Almási Attila
• Dr. Rozmer Zsuzsanna
• Dr. Tyukodi Levente