Adatok
A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2022-2023
Tantárgyfelelős
-
Dr. Tamás KÁLAI
professor,
Department of Pharmaceutical Chemistry
Óraszámok/félév
előadás: 0 óra
gyakorlat: 0 óra
szeminárium: 28 óra
összesen: 28 óra
Tárgyadatok
- Kód: OPF-HVS-T
- 2 kredit
- Pharmacy
- Optional modul
- autumn
OPA-S1E-T completed
Kurzus létszámkorlát
min. 1 fő – max. 12 fő
Campus kurzusként elérhető 3 fő számára. Campus-karok: ÁOK GYTK TTK
Tematika
Heterocyclic chemistry is an important subdivision of organic chemistry, as 70% of all medicines are heterocyclic compound or contains a heterocyclic moiety. This course will give an introduction to, and the summary of, the most important principles and ideas of heterocyclic chemistry. This course partially re-calls the knowledge of Organic chemisty 1 and Organic chemistry 2 course, discusses those details which were not reflected on, because of time shortage and supports to evaluate the pharmacological chemistry subject.
-Electronic structure of heterocycles
-Nomenclature of heterocyclic compounds
-Main synthetic routes to heterocyclic compounds, Saturated heterocycles, occurence of heterocycles
-Three and four membered heterocycles (synthesis, reactions, occurence)
-The pyrrole and indole (synthesis, reactions, occurence)
-Furan, thiophene and their benzo derivatives.
-Five membered heterocycles with two or more heteroatoms: imidazole, oxazole, thiazole
-Pyrazole, isoxazole, isothiazole
-I. st test, Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)
-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)
-Six membered heterocycles with two or more heteroatoms (purine, diazines, triazines etc.)
-Seven membered heterocyclic chemistry
-Heterocycles in supramolecular chemitry
-Heterocyclic compounds in organic snthesis
-II nd test, short presntation on a paper on heterocyclic chemistry
-Evaluation
Előadások
Gyakorlatok
Szemináriumok
- 1. Electronic structure of heterocycles, nomenclature of heterocycles
- 2. Occurence of heterocyclic compounds
- 3. Synthesis of heterocycles
- 4. Common reaction types in heterocyclic chemistry
- 5. Tautomerism in heterocyclic chemistry
- 6. Saturated heterocycles
- 7. Three and four membered heterocycles, beta lactams
- 8. Three and four-membered heterocycles and beta lactams
- 9. Synthesis of pyrroles and porfirine ring containing compounds
- 10. Synthesis of indoles, main reactions of indoles.
- 11. Furans and thiophenes
- 12. Thiophenes and benzothiophenes
- 13. 1,2-azoles, their synthesis, reactions and their occurence in drugs
- 14. 1,3-azoles, their synthesis, reactions, occurence in drugs
- 15. 1st test (generral feature of heterocyclic compounds (3-, 4-, 5-membered heterocycles)
- 16. Six membered heterocycles containing oxygen heteroatom
- 17. Pyridines (synthesis, reactions, occurence in drugs and biomolecules)
- 18. Quinolines, isoquinolines (synthesis, reactions, occurence in drugs)
- 19. Synthesis of pyrimidines and their occurence in medicines
- 20. Synthesis and reactions of 1,2- and 1,4-diazines
- 21. Synthesis and reactions of triazines and purines
- 22. Heterocycles of life and death
- 23. Seven membered heterocycles their occurence, synthesis, applications in therapy
- 24. IInd test, short presentations on papers on heterocyclic chemistry, evaluation
- 25. Heterocycles in supramolecular chemistry
- 26. Heterocycles in organic synthesis
- 27. 2nd test (6- and 7-membered heterocycles)
- 28. Short presentations, evaluations
A tananyag elsajátításához szükséges segédanyagok
Kötelező irodalom
Li, J. J. Hetrocyclic chemistry in Drug Discovery, Wiley
Saját oktatási anyag
Slides will be given to students as a ppt or pdf files.
Jegyzet
Joule, J. J.; Mills, K. Heterocyclic chemistry at a Glance. (Wiley)
Ajánlott irodalom
Li, J. J. Top 10 drugs Oxfors University Press
A félév elfogadásának feltételei
Maximum of 25 % absence allowed
Félévközi ellenőrzések
The students write two tests, at the middle of the semester and at the end of the semester. Every student have a chance to make a presentation based on a heterocyclic chemistry paper for an extra grade.
Távolmaradás pótlásának lehetőségei
Personal communication. The english program student might visit the paralell hungarian course to catch up the main reaction equations.
Vizsgakérdések
-Electronic structure of heterocycles
-Nomenclature of heterocyclic compounds
-Main synthetic routes to heterocyclic compounds
-Saturated heterocycles
-Three and four membered heterocycles (synthesis, reactions, occurence)
-The pyrrole and indole (synthesis, reactions, occurence)
-Furan, thiophene and their benzo derivatives.
-Five membered heterocycles with two or more heteroatoms
-Six-membered heterocycles with one oxygen heteroatom (piranes, chromones, flavones and coumarins)
-Six membered heterocycles with one nitrogen atom (pyridine, quinoline, isoquinoline)
-Six membered heterocycles with two or more heteroatoms (purine, diazines etc.)
-Seven membered heterocyclic chemistry
- Heterocycles in supramolecular chemitry
-Heterocyclic compounds in organic snthesis
Vizsgáztatók
Gyakorlatok, szemináriumok oktatói
- Dr. Kálai Tamás