Pharmaceutical Chemistry 1 - Theory

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2024-2025

Tematika

Introduction to the quality control of substances used in pharmaceutical compounding. Introduction to the pharmacokinetics and pharmacodynamics of drug action. Molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients with central nervous system activity.

Előadások

• 1.

  Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances.

  - Almási Attila
• 2.

  Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances.

  - Almási Attila
• 3. Physical and physicochemical methods of the European Pharmacopoeia. - Kulcsár Győző Kornél
• 4. Identification and qualitative tests of the European Pharmacopoeia. - Kulcsár Győző Kornél
• 5.

  Protein-specific test methods of the European Pharmacopoeia.

  - Almási Attila
• 6.

  Protein-specific test methods of the European Pharmacopoeia.

  - Almási Attila
• 7.

  The fate of xenobiotics in the body. The receptor theory.

  - Rozmer Zsuzsanna
• 8.

  The fate of xenobiotics in the body. The receptor theory.

  - Rozmer Zsuzsanna
• 9.

  Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions.

  - Kulcsár Győző Kornél
• 10.

  Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions.

  - Kulcsár Győző Kornél
• 11.

  Structural and physical chemical basis of drug action. Structure-activity relationships. The stereochemistry of the molecules.

  - Kulcsár Győző Kornél
• 12.

  Structural and physical chemical basis of drug action. Structure-activity relationships. The stereochemistry of the molecules.

  - Kulcsár Győző Kornél
• 13.

  Transport processes. Transporters and ion channels as drug targets.

  - Fülöpné Kiss Edit
• 14.

  Transport processes. Transporters and ion channels as drug targets.

  - Fülöpné Kiss Edit
• 15.

  Central and peripheral receptors. Receptors as drug targets.

  - Fülöpné Kiss Edit
• 16.

  Central and peripheral receptors. Receptors as drug targets.

  - Fülöpné Kiss Edit
• 17.

  Structure and functions of enzymes. Enzymes as drug targets.

  - Fülöpné Kiss Edit
• 18.

  Structure and functions of enzymes. Enzymes as drug targets.

  - Fülöpné Kiss Edit
• 19. Phase 1 metabolic transformations. - Almási Attila
• 20. Phase 1 metabolic transformations. - Almási Attila
• 21. Phase 2 metabolic transformations. - Almási Attila
• 22. Phase 2 metabolic transformations. - Almási Attila
• 23.

  General anesthetics.

  - Rozmer Zsuzsanna
• 24.

  General anesthetics.

  - Rozmer Zsuzsanna
• 25.

  Narcotic analgesics.

  - Kovács-Rozmer Katalin
• 26.

  Narcotic analgesics.

  - Kovács-Rozmer Katalin
• 27.

  Nootropic agents and analeptics.

  - Kovács-Rozmer Katalin
• 28.

  Nootropic agents and analeptics.

  - Kovács-Rozmer Katalin

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

D. A. Williams, T. L. Lemke (eds.): Foye's Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins, Philadelphia, 2013

Saját oktatási anyag

Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry I. Laboratory Experiments and Commentary, electronic educational material, PTE 2014

Zsuzsanna Rozmer, Pál Perjési: Physico-Chemical Bases of Drug Action. Electronic educational material, PTE 2015

Jegyzet

Pharmaceutical Chemistry Practice I., Laboratory manual, University of Pécs, 2015

Ajánlott irodalom

European Pharmacopoeia, EDQM Publication

Lecture notes.

A félév elfogadásának feltételei

Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Two compulsory midterm tests (on the topics of the lectures and practices) will be written during the semester on the 7th and the 12th weeks. Both of the test result should be above 60%. Students can have one retake per midterm test. Students have to write at least four mini-tests on the practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Félévközi ellenőrzések

If the student did not take part writing the midterm test, she or he can participate the retake, only. There is no chance for extra possibilities.

Távolmaradás pótlásának lehetőségei

There is no opportunity to make up missed classes.

Vizsgakérdések

Written exam covering the topics of the lectures and the laboratory practices. The result of the first part of the written exam (Minimum Written Test) should be at least 80%. In the case of the third ("C") exam the written exam is evaluated regardless the result of the Minimum Written Test. The list of the possible questions of the Minimum Written Test is announced on the Neptun system. The result of the written exam must be above 60%. The final grade is based on results of the midterm tests and the written exam. Maximum contribution of the results of the midterm tests to the total score of the written exam is 25%. Participation on the first exam is compulsory.

Vizsgáztatók

• Almási Attila
• Kovács-Rozmer Katalin
• Rozmer Zsuzsanna

Gyakorlatok, szemináriumok oktatói

• Almási Attila
• Kovács-Rozmer Katalin
• Kulcsár Győző Kornél