Organic Chemistry 1 - Practice

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2020-2021

Tematika

The aims of this course are to introduce students into several basic laboratory techniques and to demonstrate some characteristic reactions of organic compounds with various functional groups.

Előadások

Gyakorlatok

• 1. General instructions for work in the laboratory, safety precautions. Introduction to use of common laboratory apparatus. Characteristic reactions of alkanes, alkenes and alkynes.
• 2. General instructions for work in the laboratory, safety precautions. Introduction to use of common laboratory apparatus. Characteristic reactions of alkanes, alkenes and alkynes.
• 3. General instructions for work in the laboratory, safety precautions. Introduction to use of common laboratory apparatus. Characteristic reactions of alkanes, alkenes and alkynes.
• 4. Basic laboratory operations I.: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation).
• 5. Basic laboratory operations I.: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation).
• 6. Basic laboratory operations I.: Synthesis of acetanilide (heating, cooling, stirring, filtration with vacuum, crystallisation).
• 7. Basic laboratory operations II: Determination of the melting point, separation of dies with column chromatography; Characteristic tube reactions of alkanes, aromatic hydrocarbons and alkenes.
• 8. Basic laboratory operations II: Determination of the melting point, separation of dies with column chromatography; Characteristic tube reactions of alkanes, aromatic hydrocarbons and alkenes.
• 9. Basic laboratory operations II: Determination of the melting point, separation of dies with column chromatography; Characteristic tube reactions of alkanes, aromatic hydrocarbons and alkenes.
• 10. Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the boiling point); Identification of 1st unknown compound.
• 11. Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the boiling point); Identification of 1st unknown compound.
• 12. Basic laboratory operations III: Synthesis of tert-butyl-chloride (extraction, drying, filtration, distillation, determination of the boiling point); Identification of 1st unknown compound.
• 13. Synthesis of p-bromo-acetanilide and p-nitro-acetanilide. Characteristic tube reactions of alkyl halides.
• 14. Synthesis of p-bromo-acetanilide and p-nitro-acetanilide. Characteristic tube reactions of alkyl halides.
• 15. Synthesis of p-bromo-acetanilide and p-nitro-acetanilide. Characteristic tube reactions of alkyl halides.
• 16. 1st written test; Characteristic tube reactions of alcohols, phenols and ethers.
• 17. 1st written test; Characteristic tube reactions of alcohols, phenols and ethers.
• 18. 1st written test; Characteristic tube reactions of alcohols, phenols and ethers.
• 19. Synthesis of fluorenol with reduction and fluorenone with oxidation; Identification of 2nd unknown compound;
• 20. Synthesis of fluorenol with reduction and fluorenone with oxidation; Identification of 2nd unknown compound;
• 21. Synthesis of fluorenol with reduction and fluorenone with oxidation; Identification of 2nd unknown compound;
• 22. Basic laboratory operations IV: thin layer chromatography, introduction to infrared spectroscopy. Isolation of piperine.
• 23. Basic laboratory operations IV: thin layer chromatography, introduction to infrared spectroscopy. Isolation of piperine.
• 24. Basic laboratory operations IV: thin layer chromatography, introduction to infrared spectroscopy. Isolation of piperine.
• 25. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 26. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 27. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 28. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 29. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 30. Preparation of 4-amino-benzenesulfonamide and nitrobenzene.
• 31. 2nd written test. Characteristic reactions of amines.
• 32. 2nd written test. Characteristic reactions of amines.
• 33. 2nd written test. Characteristic reactions of amines.
• 34. Preparation of anthranilic acid; Identification of 3rd unknown compound.
• 35. Preparation of anthranilic acid; Identification of 3rd unknown compound.
• 36. Preparation of anthranilic acid; Identification of 3rd unknown compound.
• 37. Preparation of 2-iodobenzoic acid;
• 38. Preparation of 2-iodobenzoic acid;
• 39. Preparation of 2-iodobenzoic acid;
• 40. Evaluation.
• 41. Evaluation.
• 42. Evaluation.

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

Kálai, T., Bognár, B. Organic Chemisry Laboratory Manual, Dept. of Org. and Med. Chem., Medical Faculty, University of Pécs, 2010.

Jegyzet

Ajánlott irodalom

Charles F. Wilcox, Jr., Mary F. Wilcox: Experimental Organic Chemistry: a Small-scale Approach, 2nd ed., Prentice-Hall, London, 1995.
Dana W. Mayo, Ronald M. Pike, Peter K. Trumper: Microscale Organic Laboratory with Multistep and Multiscale Syntheses, 3rd ed., Wiley, New York, 1994.

A félév elfogadásának feltételei

Maximum of 25 % absence allowed

Félévközi ellenőrzések

The organic chemistry laboratory course will be graded (1-5), based on the two written tests on 6th and 11th week, first of all. The evaluation can be modified by grades of semi-micro preparations, success of unknown identification as well as the outlook of the records of exercise book.

Távolmaradás pótlásának lehetőségei

Students have to contact their lab TA within 48 hours of missing lab to make the necessary arrangements.

Vizsgakérdések

The written tests will contain the matter of practice.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói

• Dr. Bognár Balázs
• Dr. Kálai Tamás