Adatok
A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2019-2020
Tantárgyfelelős
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Tibor Attila RAUCH
senior research fellow,
Department of Medical Biology and Central Electron Microscope Laboratory
Óraszámok/félév
előadás: 12 óra
gyakorlat: 0 óra
szeminárium: 0 óra
összesen: 12 óra
Tárgyadatok
- Kód: OXFMLP-z-T
- 1 kredit
- Dentistry
- Optional modul
- autumn
Nincs
Kurzus létszámkorlát
min. 1 fő – max. 50 fő
Campus kurzusként elérhető 1 fő számára. Campus-karok: ÁOK TTK
Tematika
Why are certain family members affected by tumorous diseases and others are not? Can the lifestyles of our grandparents and parents affect our health? What kind of molecular factors and mechanisms might be involved in epigenetics, including transgenerational inheritance? Is epigenetics the missing link between genetics, the environment and disease? These fundamental questions will be addressed and the latest advances of the field will be discussed. Moreover, epigenetic biomarkers and therapeutic potential of epigenetic drugs (epigenetic enzyme inhibitors) will be also covered.
Előadások
- 1. Milestones of epigenetics - from Conrad Waddington to David Allis - Dr. Rauch Tibor Attila
- 2. DNA methylation and demethylation – the first discovered epigenetic alterations - Dr. Rauch Tibor Attila
- 3. Histone protein-related epigenetic signals - Dr. Rauch Tibor Attila
- 4. Non-coding RNAs (miRNA, piRNA and lncRNA) in cell biology and pathogeneses - Dr. Rauch Tibor Attila
- 5. Epigenetic methods, including single-locus and genome-wide analysis tools - Dr. Rauch Tibor Attila
- 6. Genetic imprinting and X chromosome inactivation - Dr. Rauch Tibor Attila
- 7. Stem cell and differentiation-associated epigenetic events - Dr. Rauch Tibor Attila
- 8. Epigenetics of cancer - Dr. Rauch Tibor Attila
- 9. Epigenetics of autoimmune diseases - Dr. Rauch Tibor Attila
- 10. Epigenetic aspects of memory and neurological disorders - Dr. Rauch Tibor Attila
- 11. Epigenetic biomarkers and therapeutic interventions - Dr. Rauch Tibor Attila
- 12. Exam (oral or written) - Dr. Rauch Tibor Attila
Gyakorlatok
Szemináriumok
A tananyag elsajátításához szükséges segédanyagok
Kötelező irodalom
-
Saját oktatási anyag
PowerPoint presentation according to lectures
Jegyzet
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Ajánlott irodalom
Handbook of Epigenetics, 2nd Edition, Editors: Trygve Tollefsbol, eBook ISBN: 9780128054772, Hardcover ISBN: 9780128053881, Academic Press, Published Date: 7th August 2017
A félév elfogadásának feltételei
Maximum of 15 % absence allowed
Félévközi ellenőrzések
Closing test
Távolmaradás pótlásának lehetőségei
None
Vizsgakérdések
1. Milestones of epigenetics
2. DNA methylation and demethylation
3. Histone protein-related epigenetic signals
4. Non-coding RNAs
5. Epigenetic methods
6. Genetic imprinting
7. Stem cell and differentiation-associated epigenetic events
8. Epigenetics of cancer
9. Epigenetics of autoimmune diseases
10. Epigenetic aspects of memory and neurological disorders
11. Epigenetic biomarkers and therapeutic interventions
12. X-chromosome inactivation