Molecular Cell Biology 2

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2025-2026

Tematika

Molecular cell biology aims to introduce the molecular mechanisms of molecular biology and cell biology and to emphasise their importance in medicine. It provides the basis for teaching the different areas of molecular medicine, molecular pathology, molecular diagnostics, pharmacology and gene therapy. In the second semester of the course, we will discuss signalling pathways, apoptosis signalling, types of stem cells and their medical importance. In addition to the general characteristics of tumors, we will describe the characteristics of DNA and RNA tumor viruses involved in tumorigenesis, as well as the mechanisms of activation of cellular oncogenes and inactivation of tumor suppressor genes. In addition to the multistep mechanisms of tumor development, we will discuss the latest treatment options. At the end of the semester, we will summarize molecular diagnostic techniques, types of gene therapy and their importance in medical practice.

Előadások

• 1. General information. Cell-cell junctions - Bugyi Beáta
• 2. Passive and active transport processes - Bugyi Beáta
• 3. Extracellular matrix. Cell-extracellular matrix connections - Bugyi Beáta
• 4. Signal transduction I. Signaling molecules and their receptors - Schipp Renáta
• 5. Signal transduction II. Role of G-proteins in signaling - Feketéné Kiss Katalin
• 6. Signal transduction III. Growth factor signaling - Sétáló György ifj.
• 7. Signal transduction IV. Stress signaling - Bátor Judit
• 8. Signal transduction V. Cytokine- and integrin signaling - Berta Gergely
• 9. Signal transduction VI. TGFb-, Wnt-, Heghehog-, Notch signaling - Feketéné Kiss Katalin
• 10. Signal transduction VII. General conclusions, clinical aspects - Varga Judit
• 11. Types of cell death - Bátor Judit
• 12. Apoptosis pathways, physiological and pathological importance - Bátor Judit
• 13. Types of stem cells and their medical importance - Pap Marianna
• 14. General features of tumor cells and tumors - Varga Judit
• 15. DNA tumor viruses - Sétáló György ifj.
• 16. RNA tumor viruses - Sétáló György ifj.
• 17. Cellular oncogenes I. - Pap Marianna
• 18. Cellular oncogenes II. - Pap Marianna
• 19. Cellular oncogenes III. - Pap Marianna
• 20. Tumor szuppressor genes I. - Sétáló György ifj.
• 21. Tumor szuppressor genes II. - Sétáló György ifj.
• 22. Role of oncogenes in tumor formation - Pap Marianna
• 23. Multistep carcinogenesis I.: Experimental carcinogenesis - Pap Marianna
• 24. Multistep carcinogenesis II.: Clinical stages of cancers - Pap Marianna
• 25. Therapy of cancers - Pap Marianna
• 26. Molecular diagnosis - Berta Gergely
• 27. Gene therapy I. - Bátor Judit
• 28. Gene therapy II. Exam rules - Stayer-Harci Alexandra

Gyakorlatok

• 1. Isolation and restriction en+G2:G55donulease cleavage of human DNA
• 2. Isolation and restriction endonulease cleavage of human DNA
• 3. Polymerase chain reaction
• 4. Polymerase chain reaction
• 5. Immunocytochemistry
• 6. Immunocytochemistry
• 7. Signaling: Functional imaging of cells and tissues
• 8. Signaling: Functional imaging of cells and tissues
• 9. Apoptosis
• 10. Apoptosis
• 11. Tumor biology
• 12. Tumor biology

Szemináriumok

• 1. Cytoskeleton
• 2. Cell membrane, cell-cell junctions
• 3. Passive and active transport processes
• 4. Extracellular matrix, cell-extracellular matrix connections
• 5. Types of chemical signaling. Receptors.
• 6. Signal transduction mechanism: The cAMP pathway
• 7. Signal transduction mechanisms: the phospholipase C pathway. Growth factor and cytokine signaling
• 8. Apoptosis. Stem cells
• 9. General features of tumors
• 10. DNA and RNA tumor viruses
• 11. Cellular oncogenes
• 12. Tumor suppressor genes. Oncogenes and the cell cycle
• 13. Multistep mechanism of carcinogenesis
• 14. Therapy of tumors. Molecular medicine
• 15. Semester test
• 16. Semester test

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Cooper, G.M.: The Cell. A Molecular Approach.

Saját oktatási anyag

PotePedia materials

Materials uploaded to the MS Teams lecture group

Test bank questions

Minimum requirement test questions

Jegyzet

Molecular Cell Biology Laboratory Manual

Szeberényi, J., M. Pap (editor): Molecular Cell Biology Syllabus

Ajánlott irodalom

Lodish et al.: Molecular Cell Biology

Alberts et al.: Molecular Biology of the Cell

A félév elfogadásának feltételei

Completion of all practices, confirmed by the instructor's signature. No more absences from seminars and practices than allowed. According to the application of the provision of Section 1/A (6) of the Code of Studies and Examinations to small group sessions (seminars, practices).

Félévközi ellenőrzések

Mid-term and end-of-semester written tests. The dates and topics of the tests will be announced during the lecture and in the Molecular Cell Biology lecture Teams group. There is no possibility for retakes for any of the written tests. Based on the combined results of the mid-term tests, exemption from the exam can be obtained.

Távolmaradás pótlásának lehetőségei

Due to absences, make-up practicals can be attended at make-up sessions organized by the Department.

Mid-term tests can be made up according to the options designated by the course leader. There is no possibility to make up the end-of-semester test.

Vizsgakérdések

Available on PotePedia and uploaded to the MS Teams lecture group.

Vizsgáztatók

• Atlaszné Váczy Alexandra
• Balassa Tímea
• Balogh Bálint
• Bátor Judit
• Berta Gergely
• Bogdán Ágnes
• Boros Melinda
• Bugyi Beáta
• Csabai-Tanics Tímea Judith
• Feketéné Kiss Katalin
• Gaszler Péter
• Horváth Marianna
• Leipoldné Vig Andrea Teréz
• Németh Marica
• Pap Marianna
• Rátky Fanni
• Schipp Renáta
• Sétáló György ifj.
• Stayer-Harci Alexandra
• Szütsné Tóth Mónika Ágnes
• Tarjányi Oktávia
• Varga Judit

Gyakorlatok, szemináriumok oktatói

• KURZUSHOZ RENDELT OKTATÓ