Great Discoveries in Pharmacology

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2022-2023

Tematika

The aim of the lectures is to show how and through what discoveries pharmaceutical science came to today's modern age. Thanks to the famous scientists presented their achieved breakthroughs in their own age have fundamentally changed scientific thinking. Pharmacology has a rich and long-standing heritage, which today completed with new disciplines such as molecular biology and genetics, which provide powerful tools for study pharmacodynamics and pharmacokinetics. During the semester, students will gain insight into the pharmacological methods in those ages when researchers achieved their world-famous discoveries without today’s sophisticated tools.

Előadások

• 1. Important principles of drug treatments: Sir James Black, Gertrude Elion és és Geroge Hitchins. - Hartnerné Dr. Pohóczky Krisztina
• 2. Discoveries of János Kabay. - Hartnerné Dr. Pohóczky Krisztina
• 3. The discovery of penicillin and its curative effects in various infectious diseases: Sir Alexander Fleming, Cecil Paine, Harold Raistrick, Ernst Chain, and Sir Howard Florey. - Hartnerné Dr. Pohóczky Krisztina
• 4. The scientific impact of Antal Bayer. - Hartnerné Dr. Pohóczky Krisztina
• 5. The roles of prostaglandins and related biologically active substances: Sune Bergstrom, Bengt Samuelsson, and John Vane. - Hartnerné Dr. Pohóczky Krisztina
• 6. Richter Gedeon and the kalmopyrin. - Hartnerné Dr. Pohóczky Krisztina
• 7. Discovery of cyclic AMP and protein phosphorylation as a key mechanism in the regulation of cellular function: Earl W. Sutherland, Edwin G. Krebs and Edmond H. Fischer. - Hartnerné Dr. Pohóczky Krisztina
• 8. Career and research of Albert Szent-Györgyi. - Hartnerné Dr. Pohóczky Krisztina
• 9. G proteins and their role in signal transduction: Rodbell and Alfred G. Gilman. - Hartnerné Dr. Pohóczky Krisztina
• 10. Life and researh of Louis Pasteur. - Hartnerné Dr. Pohóczky Krisztina
• 11. The history of chemotherapy: from the chemical weapons to Sydney Farber. - Dr. Szőke Éva
• 12. History of capsaicin research, discovery of capsaicin-sensitive sensory nerve endings and their role: Miklós Jancsó and János Szolcsányi. - Dr. Szőke Éva
• 13. Nitric oxide as a signaling molecule of the cardiovascular system: Robert Furchgott, Ferid Murad és Louis Ignarro. - Hartnerné Dr. Pohóczky Krisztina
• 14. József Béres; inventor and scientist. - Hartnerné Dr. Pohóczky Krisztina

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

Own educational material will be available in digital form in the Neptun Meet Street.

Jegyzet

Ajánlott irodalom

Ronald P. Rubin: A brief history of great discoveries in pharmacology: in celebration of the centennial anniversary of the founding of the american society of pharmacology and experimental therapeutics, 2007: Pharmacological Reviews 59: 289-359.

A félév elfogadásának feltételei

Maximum of 15 % absence allowed

Félévközi ellenőrzések

During the semester, each student have to give a short presentation on a chosen topic related to drug discovery.

Távolmaradás pótlásának lehetőségei

There is no possibility to make up the lectures.

Vizsgakérdések

The final mark will based on the short oral presentation of a famous discovery or famous researcher.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói