Autoimmune disease development: Genetic, Environmental, and Lifestyle Factors

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2025-2026

Thematik

Course Objectives

·         Introduction to autoimmune diseases and exploring their pathomechanism.

·         Identify key risk factors and understand their interplay for the development of autoimmune diseases.

·         Analyze the impact of lifestyle factors (smoking, diet, exercise) on autoimmune risk.

·         Discuss the role of infections and microbial dysbiosis.

·         Evaluate the influence of gender and hormonal factors.

·         Explore the role of environmental toxins and occupational exposures.

·         Assessment of scientific literature on autoimmune risk factors.

Vorlesungen

• 1. ·         Introduction to autoimmunity·         Definition and classification of autoimmune diseases. - Meggyes-Rapp Judit
• 2. ·         Pathogenesis of autoimmunity: immune dysregulation, disturbance in tolerance, autoantibody secretion, cellular and signaling mechanisms.Common autoimmune diseases including clinical manifestations, diagnosis and current therapies - Meggyes-Rapp Judit
• 3. ·         Genetic susceptibility, Human Leukocyte Antigen (HLA) complex and thei role in autoimmunity·         Single nucleotide polymorphisms (SNPs) and their association with autoimmune risk - Olasz Katalin Eszter
• 4. ·         Familial clustering and genetic testing of autoimmune diseases·         The risk of multiple autoimmunity: co-occurrence of autoimmune diseases·         Medication side effects: drug- induced autoimmunity - Olasz Katalin Eszter
• 5. ·         Infections: Role of viral, bacterial, and parasitic infections. Molecular mimicry and cross-reactivity.·         Dysbiosis: The gut microbiome and its influence on the immune system. Probiotics, prebiotics, and fecal microbiota transplantation. Smoking: Impact of smoking on the immune system - Olasz Katalin Eszter
• 6. ·         Obesity: Adipose tissue as an endocrine organ.·         Metabolic syndrome and autoimmune risk.·         Diet: Nutritional factors and their impact on the immune system. Role of antioxidants, vitamins, and minerals.·         Environmental Triggers: Exposure to toxic agents: heavy metals, pesticides, and air pollution. Occupational exposures and autoimmune risk. - Olasz Katalin Eszter
• 7. ·         Epidemiology of autoimmune diseases·         Gender bias: female predominance in many autoimmune diseases. - Olasz Katalin Eszter
• 8. ·         Hormonal influences: the role of estrogen, progesterone, and androgens.·         Pregnancy and autoimmune disease. - Olasz Katalin Eszter
• 9. ·         Epigenetics and autoimmunity - Meggyes-Rapp Judit
• 10. ·         Epigenetic mechanisms: DNA methylation, histone modifications, and non-coding RNAs.·         Epigenetic changes in autoimmune diseases. - Meggyes-Rapp Judit
• 11. ·         Research methods used in autoimmune disease studies·         Epidemiological approaches: case-control and prospective cohort studies - Meggyes-Rapp Judit
• 12. ·         Genetic association studies: genome-wide association studies (GWAS).·         Critical appraisal of scientific literature: evaluating study design, bias and validity. - Meggyes-Rapp Judit

Praktika

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

PPT files of the course

Vom Institut veröffentlichter Lehrstoff

Skript

Empfohlene Literatur

Voraussetzung zum Absolvieren des Semesters

Case study presentations / Presentation of a peer-reviewed research article or original research findings within a journal club session

Semesteranforderungen

nincs

Möglichkeiten zur Nachholung der Fehlzeiten

nem

Prüfungsfragen

Case study presentations / Presentation of a peer-reviewed research article or original research findings within a journal club session

Prüfer

• Meggyes-Rapp Judit
• Olasz Katalin Eszter

Praktika, Seminarleiter/innen