Drug Metabolism and Drug Toxicity

Daten

Offizielle Daten in der Fachveröffentlichung für das folgende akademische Jahr: 2020-2021

Thematik

On the seminaries of this facultative course the molecular background and the influenceability of the side and toxic effects of different drugs are aimed, during the drug absorption, drug transformation and drug elimination.
During the course, the metabolic activation and transformation of the environmental carcinogens are to be discussed.

Vorlesungen

• 1. Introduction. The toxicological aspects of drug metabolism. - Dr. Almási Attila
• 2. Characteristics of xenobiotics in the body - Dr. Almási Attila
• 3. Metabolic transformation I. Phase I. or functionalisation reactions 1 (CYP enzymes). - Dr. Almási Attila
• 4. Metabolic transformations II. Phase I. or functionalisation reactions 2 (FAD enzymes and non microsomal transformations). - Dr. Almási Attila
• 5. Metabolic transformations III. Phase II. or conjugation reactions 1 ( glucuronic acid conjugation, sulphate conjugation). - Dr. Almási Attila
• 6. Metabolic transformations IV. Phase II. or conjugation reactions 2 ( amino acid conjugation, acetylation, methylation, gluthatione conjugation). - Dr. Almási Attila
• 7. Phase III. transformations (transporters), general molecular mechanism of drug toxicity. - Dr. Almási Attila
• 8. Biotransformation and the toxic effects of the paracetamol. Factors influence the toxicity of the paracetamol. - Dr. Almási Attila
• 9. Toxicity of the non-steroid antiinflammatory drugs (NSAIDs). Hepatotoxic effect of the diclofenac. - Dr. Almási Attila
• 10. Toxicity of the troglitazone. Sulfonamide hypersensitivity. - Dr. Almási Attila
• 11. Chemical carcinogenesis I., Definition, cell division, environmental carcinogens, chemical carcinogenesis. - Dr. Almási Attila
• 12. Chemical carcinogenesis II., Structure and metabolic activation of environmental carcinogens. - Dr. Almási Attila
• 13. Metabolic differences between species, genetic polymorphism. - Dr. Almási Attila
• 14. Changes in drug metabolism during pregnancy and at aged people. - Dr. Almási Attila

Praktika

Seminare

Materialien zum Aneignen des Lehrstoffes

Obligatorische Literatur

Vom Institut veröffentlichter Lehrstoff

Slides of the lectures.

Skript

Empfohlene Literatur

Voraussetzung zum Absolvieren des Semesters

Maximum of 25 % absence allowed

Semesteranforderungen

In the end of the semester the students write an end-semester test. The test is evaluated in percentage and the final grade is to be established based on this result. The result of the test should be above 60%.

Möglichkeiten zur Nachholung der Fehlzeiten

The replacement of the missed test is required.

Prüfungsfragen

Based on the announced thesis list.

Prüfer

Praktika, Seminarleiter/innen

• Dr. Almási Attila