Drug Metabolism and Drug Toxicity

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2020-2021

Tematika

On the seminaries of this facultative course the molecular background and the influenceability of the side and toxic effects of different drugs are aimed, during the drug absorption, drug transformation and drug elimination.
During the course, the metabolic activation and transformation of the environmental carcinogens are to be discussed.

Előadások

• 1. Introduction. The toxicological aspects of drug metabolism. - Dr. Almási Attila
• 2. Characteristics of xenobiotics in the body - Dr. Almási Attila
• 3. Metabolic transformation I. Phase I. or functionalisation reactions 1 (CYP enzymes). - Dr. Almási Attila
• 4. Metabolic transformations II. Phase I. or functionalisation reactions 2 (FAD enzymes and non microsomal transformations). - Dr. Almási Attila
• 5. Metabolic transformations III. Phase II. or conjugation reactions 1 ( glucuronic acid conjugation, sulphate conjugation). - Dr. Almási Attila
• 6. Metabolic transformations IV. Phase II. or conjugation reactions 2 ( amino acid conjugation, acetylation, methylation, gluthatione conjugation). - Dr. Almási Attila
• 7. Phase III. transformations (transporters), general molecular mechanism of drug toxicity. - Dr. Almási Attila
• 8. Biotransformation and the toxic effects of the paracetamol. Factors influence the toxicity of the paracetamol. - Dr. Almási Attila
• 9. Toxicity of the non-steroid antiinflammatory drugs (NSAIDs). Hepatotoxic effect of the diclofenac. - Dr. Almási Attila
• 10. Toxicity of the troglitazone. Sulfonamide hypersensitivity. - Dr. Almási Attila
• 11. Chemical carcinogenesis I., Definition, cell division, environmental carcinogens, chemical carcinogenesis. - Dr. Almási Attila
• 12. Chemical carcinogenesis II., Structure and metabolic activation of environmental carcinogens. - Dr. Almási Attila
• 13. Metabolic differences between species, genetic polymorphism. - Dr. Almási Attila
• 14. Changes in drug metabolism during pregnancy and at aged people. - Dr. Almási Attila

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

Slides of the lectures.

Jegyzet

Ajánlott irodalom

A félév elfogadásának feltételei

Maximum of 25 % absence allowed

Félévközi ellenőrzések

In the end of the semester the students write an end-semester test. The test is evaluated in percentage and the final grade is to be established based on this result. The result of the test should be above 60%.

Távolmaradás pótlásának lehetőségei

The replacement of the missed test is required.

Vizsgakérdések

Based on the announced thesis list.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói

• Dr. Almási Attila