Genetic Background of Gene Manipulation II

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2023-2024

Tematika

The subject expands on the knowledge which was accumulated in the previous semester. Gene mutation, DNA repair mechanisms and transposition, regulation of gene expression, transcriptional and post-transcriptional regulation will be discussed. Finally, epigenetic regulation of gene expression and its consequences will be the final topic.

Előadások

• 1. Gene mutations - Dr. Pongrácz Judit Erzsébet
• 2. Replication errors and Base modifications - Dr. Pongrácz Judit Erzsébet
• 3. Induced mutations induced by chemicals and radiation I. - Dr. Pongrácz Judit Erzsébet
• 4. Induced mutations induced by chemicals and radiation II. - Dr. Pongrácz Judit Erzsébet
• 5. Mutations in the background of human diseases I. - Dr. Pongrácz Judit Erzsébet
• 6. Mutations in the background of human diseases II. - Dr. Pongrácz Judit Erzsébet
• 7. Transposable elements - Dr. Pongrácz Judit Erzsébet
• 8. Regulation of gene expression in bacteria - Dr. Pongrácz Judit Erzsébet
• 9. Regulation of gene expression in Eukaryotes - Dr. Pongrácz Judit Erzsébet
• 10. Transcriptional regulation in Eukaryotes - Dr. Pongrácz Judit Erzsébet
• 11. The epigenome - Dr. Pongrácz Judit Erzsébet
• 12. Regulation of the epigenome - Dr. Pongrácz Judit Erzsébet
• 13. Epigenetics and diseases - Dr. Pongrácz Judit Erzsébet
• 14. Epigenetic traits - Dr. Pongrácz Judit Erzsébet

Gyakorlatok

• 1. Sequence alignments
• 2. Sequence alignments
• 3. Sequence alignments
• 4. Sequence alignments
• 5. The effect of UV irradiation on cellular morphology and function
• 6. The effect of UV irradiation on cellular morphology and function
• 7. The effect of UV irradiation on cellular morphology and function
• 8. The effect of UV irradiation on cellular morphology and function
• 9. The effect of UV irradiation on gene expression
• 10. The effect of UV irradiation on gene expression
• 11. The effect of UV irradiation on gene expression
• 12. The effect of UV irradiation on gene expression
• 13. BLASTS - bioinformatics
• 14. BLASTS - bioinformatics
• 15. BLASTS - bioinformatics
• 16. BLASTS - bioinformatics
• 17. Designing disease models - Chromosomal modification - Downsyndrome mouse model
• 18. Designing disease models - Chromosomal modification - Downsyndrome mouse model
• 19. Designing disease models - Chromosomal modification - Downsyndrome mouse model
• 20. Designing disease models - Chromosomal modification - Downsyndrome mouse model
• 21. Designing disease models - transposons
• 22. Designing disease models - transposons
• 23. Designing disease models - transposons
• 24. Designing disease models - transposons
• 25. Swiss prot - protein sequences in disease analysis
• 26. Swiss prot - protein sequences in disease analysis
• 27. Swiss prot - protein sequences in disease analysis
• 28. Swiss prot - protein sequences in disease analysis

Szemináriumok

• 1. Replication errors and Base modifications
• 2. Replication errors and Base modifications
• 3. Induced mutations induced by chemicals
• 4. Induced mutations induced by radiation
• 5. Mutations in the background of human diseases case study I.
• 6. Mutations in the background of human diseases case study II.
• 7. Mutations in the background of human diseases case study III.
• 8. Comparison of gene expression regulation in bacteria and humans I.
• 9. Comparison of gene expression regulation in bacteria and humans II.
• 10. Comparison of gene expression regulation in bacteria and humans III.
• 11. Comparison of gene expression regulation in bacteria and humans IV.
• 12. Epigenetics in the background of human diseases case study I.
• 13. Epigenetics in the background of human diseases case study II.
• 14. Epigenetics in the background of human diseases case study III.

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

Own ppt, interactive teaching material

Jegyzet

Ajánlott irodalom

Klug et al: Concepts of Genetics 12th Edition
Pierce: Genetics - A Conceptual Approach 7th Edition (2020)

A félév elfogadásának feltételei

Maximum of 15 % absence allowed

Félévközi ellenőrzések

One midterm test, that can be repeated two more times if necessary.

Távolmaradás pótlásának lehetőségei

None

Vizsgakérdések

Teams, Neptun, Departmental website

Vizsgáztatók

• Dr. Pongrácz Judit Erzsébet
• Garai Kitti

Gyakorlatok, szemináriumok oktatói

• Ádám Zoltán Mihály
• Garai Kitti