Pharmacology and Biotechnology in Medical Practice

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2024-2025

Tematika

The aims of the course are: showing the history of the drug research and modes of the drug development, presenting information about the phases of rational drug design, from the plan of the molecules to clinical trials.The aim of the course is to provide an overview of drug development and introduce its methodology. The students will hear about rational drug design, starting from molecular design to clinical tirals. General pharmacology: Farmakokinetics, absorption, repartition, biotransformation, excretion. Farmakodinamics, drug binding targets, receptors, efficacy studies. Detection of the effects at various levels (molecular, cell, organ, organism). Dose dependency. Drug selectivity and safety. Tolerance. Drug interactions. Products suitable for gene therapy and their pharmacological characteristics. Immune pharmacology: target molecules of biotechnological products that influence the immune system. Monoclonalis antitestek, citokinek farmakoterápiás hatásai, mellékhatásai. Unexpected inflammation and allergic reactions. Citokine release syndrome. Oncopharmacology: Monoclonal antibodies, colony stimulating factors, interleukins in pharmacotherapy, side-effects. Fermentation of Antibiotics, antifungals, antivirals and their pharmacology. Pharmacotherapy of endokrin diseases using recombinant hormones and peptides. Optimization of results. Pharmacological products prepared from human blood. Production and quality control of cellular products suitable for human therapy.

Előadások

• 1. History of drugs - Szőke Éva
• 2. History of drugs - Szőke Éva
• 3. Strategies of drug development - Szőke Éva
• 4. Strategies of drug development - Szőke Éva
• 5. Target validation - Szőke Éva
• 6. Target validation - Szőke Éva
• 7. High throughput screening - Szőke Éva
• 8. High throughput screening - Szőke Éva
• 9. Preclinical testing - Szőke Éva
• 10. Preclinical testing - Szőke Éva
• 11. Preclinical testing - Szőke Éva
• 12. Preclinical testing - Szőke Éva
• 13. Mechanisms of drug actions - Csekő Kata
• 14. Mechanisms of drug actions - Csekő Kata
• 15.

  Quantitative pharmadynamics

  - Szőke Éva
• 16.

  Quantitative pharmadynamics

  - Szőke Éva
• 17. Pharmacokinetic aspects of drug development - Csekő Kata
• 18. Pharmacokinetic aspects of drug development - Csekő Kata
• 19. Pharmacokinetic aspects of drug development - Csekő Kata
• 20. Pharmacokinetic aspects of drug development - Csekő Kata
• 21. Toxicity testing - Szőke Éva
• 22. Toxicity testing - Szőke Éva
• 23. Human phase studies - Szőke Éva
• 24. Human phase studies - Szőke Éva
• 25. Human phase studies - Szőke Éva
• 26. Human phase studies - Szőke Éva
• 27. GMP, GLP, GCP - Szőke Éva
• 28. GMP, GLP, GCP - Szőke Éva

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

Jegyzet

Ajánlott irodalom

1. Povl Krogsgaard-Larsen, Tommy Liljefors, Ulf Madsen: Textbook of Drug Design and Discovery, 3rd edition, New York, Oxford University Press

2. Edward Harvel Kerns, Li Di: Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization, Academic Press, 2008

3. Ronald P. Evens: Drug and Biological Development: From Molecule to Product and Beyond, Springer, 2007

4. Rick Ng: Drugs: From Discovery to Approval, 2nd edition, Wiley-Blackwell, 2008

5. Bert Spilker: Guide to Drug Development: A Comprehensive Review and Assessment, Kluwer, 2008

6.Textbook of Drug Design and Discovery, Third Edition by Povl Krogsgaard-Larsen, Tommy Liljefors, Ulf Madsen, New York, Oxford University Press, 2. Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization by Edward Harvel Kerns, Li Di, Academic Press, 2008; 3. Drug and Biological Development: From Molecule to Product and Beyond by Ronald P. Evens, Springer, 2007; 4. Drugs: Fro

A félév elfogadásának feltételei

Obtaining a satisfactory grade in the written exam

Félévközi ellenőrzések

none

Távolmaradás pótlásának lehetőségei

none

Vizsgakérdések

written test

Vizsgáztatók

• Szőke Éva

Gyakorlatok, szemináriumok oktatói

• Csekő Kata
• Szőke Éva