Modern Drug Developmental Techniques - from the Molecules to the Human Clinical Studies

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2024-2025

Tematika

We will talk about what is the reason of drug development, about the history of drug development. We will compare the traditional drug discovery and modern drug development. Students will learn about target identification and validation, drug design and synthesis, selection and testing of lead molecules. They will learn about in vitro, ex vivo and in vivo preclinical drug development and in vivo animal models od pain, behavioral studies, depression and anxiety. They will learn about clinical phase trials.

Előadások

• 1. Basic concepts of pharmacology. What is the reason of drug development? - Szőke Éva
• 2. History of drug development. - Szőke Éva
• 3. Traditional drug discovery and modern drug development. - Szőke Éva
• 4. How we identify our drug target? - Szőke Éva
• 5. Design and synthesis of drug molecules. - Szőke Éva
• 6. Selection and testing of lead molecules. - Szőke Éva
• 7. Testing of drug candidates, in vitro preclinical development. - Szőke Éva
• 8. Testing of drug candidates, ex vivo preclinical development. - Szőke Éva
• 9. In vivo animal experiments in drug development: pain models. - Szőke Éva
• 10. In vivo animal experiments in drug development: behavioral studies, depression, anxiety studies. - Szőke Éva
• 11. Clinical phase trials. - Szőke Éva
• 12. Discussion of papers. - Szőke Éva

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

Materials is pdf format.

Jegyzet

Ajánlott irodalom

A félév elfogadásának feltételei

A 2 pages-paper about the topic of the course.

Félévközi ellenőrzések

A small paper about the topic of the course.

Távolmaradás pótlásának lehetőségei

In agreement with the lecturer.

Vizsgakérdések

1. Basic concepts of pharmacology. What is the reason of drug development?

2. History of drug development.

3. Traditional drug discovery and modern drug development.

4. How we identify our drug target?

5. Design and synthesis of drug molecules.

6. Selection and testing of lead molecules.

7. Testing of drug candidates, in vitro preclinical development.

8. Testing of drug candidates, ex vivo preclinical development.

9. In vivo animal experiments in drug development: pain models.

10. In vivo animal experiments in drug development: behavioral studies, depression, anxiety studies.

11. Clinical phase trials.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói