Drug Design 2

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2021-2022

Tematika

The course is a continuation of its parent course Drug Design. Additional details of selected topics of the parent course and also new topics are provided. In Journal Club sessions, recent research articles will be featured with the students to deepen their knowledge in the areas discussed during the previous lectures. In this way, the students can discover further connections themselves and make sure of the usefulness of their newly obtained knowledge in drug design. The lectures will take place weekly or (if possible) contracted into 4 blocks.

Előadások

• 1. Rational design: main concepts, phases, and techniques - Dr. Hetényi Csaba
• 2. Target-based optimization. Case study: ACE inhibitors - Dr. Hetényi Csaba
• 3. Ligand libraries, combinatorial synthesis, screening, modifications, and the pharmacophore. Case study: Artemisinin - Dr. Hetényi Csaba
• 4. Antiviral design - Dr. Hetényi Csaba
• 5. Antibacterial design - Dr. Zsidó Balázs Zoltán
• 6. Targeting ion channels - Dr. Zsidó Balázs Zoltán
• 7. Targeting receptors 1. - Dr. Zsidó Balázs Zoltán
• 8. Targeting receptors 2. - Dr. Zsidó Balázs Zoltán
• 9. Targeting the signaling pathways - Dr. Zsidó Balázs Zoltán
• 10. Journal club 1. Mechanisms and ligand optimizations - Dr. Hetényi Csaba
• 11. Journal club 2. Anti-cancer agents and ion channels - Dr. Hetényi Csaba
• 12. Test - Dr. Hetényi Csaba

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

Saját oktatási anyag

The material of the course including pdfs of lectures and lists of questions will be made downloadable from the web site of the Department of Pharmacology and Pharmacotherapy or a link will be provided during the lectures / in an e-mail.

Jegyzet

Ajánlott irodalom

Patrick GL: An Introduction to Medicinal Chemistry, Oxford University Press

A félév elfogadásának feltételei

Maximum of 25 % absence allowed

Félévközi ellenőrzések

There is a final test announced at the end of the semester. The test will include multiple choice questions or short essays. A mark is offered according to the results of the written test or optionally by evaluation of the student's presentation prepared for the Journal Club. The student can improve the mark according to university regulations.

Távolmaradás pótlásának lehetőségei

Replacement is possible according to personal consultation.

Vizsgakérdések

Lists of questions will be provided at the end of each lecture specifying the required knowledge.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói