Signal Transduction

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2021-2022

Tematika

Novel antibodies against receptors, protein kinase inhibitors, and antisense oligonucleotides targeting both signal transduction and gene expression will predominate the therapeutic approaches in the coming decades. The course focus on the therapeutic potential for targeting cell signaling mechanisms with particular attention to cancer therapies and inflammatory signaling pathways as well as immunomodulation. General concepts of inter-and intracellular signal transduction: receptor-mediated signal transduction, cell surface receptors, steroid hormone and nuclear receptors and their cytoplasmic signal transduction and nuclear responses, apoptotic cell signaling will be discussed together with the novel approaches to drug discovery in signal transduction.

Előadások

• 1. Introduction, overlap with other disciplines. - Dr. Boldizsár Ferenc
• 2. Overview of extracellular signaling. - Dr. Boldizsár Ferenc
• 3. Families of extracellular receptors. - Dr. Boldizsár Ferenc
• 4. Second messengers (cAMP). - Dr. Boldizsár Ferenc
• 5. Receptor tyrosine kinases. - Dr. Boldizsár Ferenc
• 6. The Ca2+ signal. - Dr. Boldizsár Ferenc
• 7. Transcription factors. - Dr. Boldizsár Ferenc
• 8. T cell activation and signaling. - Dr. Boldizsár Ferenc
• 9. Signaling in the specific immune system: B cell signaling. - Dr. Boldizsár Ferenc
• 10. Cytokine/chemokine signaling - Dr. Boldizsár Ferenc
• 11. Receptors with intrinsic enzymatic activity (insulin, growth factors). - Dr. Najbauer József
• 12. G-protein-linked receptors (epinephrine, serotonin, glucagon). - Dr. Najbauer József
• 13. Signaling in tumor cells (EGF-R, Her-2R, adhesion molecules). - Dr. Najbauer József
• 14. Intracellular/nuclear receptor signaling (steroid hormones and thyroxin). - Dr. Boldizsár Ferenc
• 15. Non-genomic steroid hormone signaling pathways. Receptor interactions, signaling cross-talk. - Dr. Boldizsár Ferenc
• 16. Apotosis signaling. - Dr. Boldizsár Ferenc
• 17. Fc gamma Receptor signaling - Dr. Berki Timea
• 18. Fc epsilon Receptor signaling - Dr. Berki Timea
• 19. Signaling in the innate immune system: CR signaling. - Dr. Najbauer József
• 20. Signaling in the innate immune system: TLR signaling. - Dr. Najbauer József
• 21. Signaling in the nervous system (Neurotransmitters). - Dr. Najbauer József
• 22. Ion channels. (Acetylcholine) - Dr. Najbauer József
• 23. Wnt receptor signaling. - Dr. Boldizsár Ferenc
• 24. Pharmacological influence of the signaling. - Dr. Boldizsár Ferenc

Gyakorlatok

Szemináriumok

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

2. Gutkind, J. Silvio (ed.): Signal Transduction and Human Disease, John Wiley & Sons, Inc.

Saját oktatási anyag

www.immbio.hu

Jegyzet

1. Gerhard Krauss: Biochemistry of Signal Transduction and Regulation, Finkel, Toren (ed.), Wiley

Ajánlott irodalom

Frederick Marcus: Bioinformatics and Systems Biology: Collaborative Research and Resources, Springer, 2008

A félév elfogadásának feltételei

Maximum of 25 % absence allowed

Félévközi ellenőrzések

During the lectures online testing will be performed and the evaluation will be based on these results.

Távolmaradás pótlásának lehetőségei

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Vizsgakérdések

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Vizsgáztatók

Gyakorlatok, szemináriumok oktatói