Adatok
A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2021-2022
Tantárgyfelelős
-
Dr. Ferenc BOLDIZSÁR
associate professor,
Department of Immunology and Biotechnology
Óraszámok/félév
előadás: 28 óra
gyakorlat: 28 óra
szeminárium: 0 óra
összesen: 56 óra
Tárgyadatok
- Kód: OAA-IMM-T
- 4 kredit
- General Medicine
- Basic modul
- spring
OAA-EL1-T completed , OAA-MB2-T completed , OAA-SF2-T completed
Vizsgakurzus:Igen
Kurzus létszámkorlát
min. 5 fő – max. 200 fő
Campus kurzusként elérhető 20 fő számára. Campus-karok: ETK TTK
Tematika
Introduction to the current immunobiology. Construction of the human immune system: organs, tissues, cellular and molecular components. Organisation and regulation of immune functions: recognition, differentiation, effector functions and memory formation. Main aspects of the physiological and pathological immune functions. Basic immunopathological aspects of immune related diseases including autoimmune diseases, organ transplantation, allergy, immunity against tumors.
Előadások
- 1. Introduction. - Dr. Németh Péter János
- 2. Molecular components of the immune system. - Dr. Németh Péter János
- 3. Recognition molecules. Recognition by MHC. - Dr. Németh Péter János
- 4. Antigen presentation and MHC restriction. - Dr. Németh Péter János
- 5. Communication between the cellular components of the immune system. - Dr. Németh Péter János
- 6. Adhesion molecules, co-receptors, cytokines, cytokine receptors. - Dr. Németh Péter János
- 7. The complement system. - Dr. Berki Timea
- 8. Innate immunity: inflammation, leukocyte migration. - Dr. Engelmann Péter András
- 9. Organization and rearrangement of the antigen receptor genes. - Dr. Balogh Péter
- 10. Primary B cell development: developmental stages and checkpoints. - Dr. Balogh Péter
- 11. T-cell development in the thymus. Stages of maturation and the role of environmental factors. - Dr. Boldizsár Ferenc
- 12. Beginning of the immune response: early stages of T/B cell interaction, CD3 complex and signal transduction, BcR signal transduction. Co-stimulation. T-dependent - Dr. Boldizsár Ferenc
- 13. Components of the humoral immune response: extrafollicular reaction and germinal center. - Dr. Balogh Péter
- 14. Immunological memory. - Dr. Balogh Péter
- 15. Effector functions of immunoglobulins. Antigen-antibody reactions. IgE mediated immunereactions. - Dr. Berki Timea
- 16. Effector mechanisms of cell-mediated immune responses: 1. Cytotoxicity, 2. Th cell-mediated macrophage activation (Delayed type hypersensitivity=DTH) - Dr. Berki Timea
- 17. Allergies and hypersensitive reactions. - Dr. Boldizsár Ferenc
- 18. Allergies and hypersensitive reactions. - Dr. Boldizsár Ferenc
- 19. Systemic and local immunity (SALT, MALT). - Dr. Németh Péter János
- 20. Suppression of the immune response. - Dr. Németh Péter János
- 21. Immunological tolerance. - Dr. Németh Péter János
- 22. Autoimmunity and autoimmune diseases. - Dr. Németh Péter János
- 23. Primary immunodeficiencies. - Dr. Balogh Péter
- 24. Acquired immunodeficiencies, pathomechanism and progression of AIDS, diagnostic and therapeutic possibilities. - Dr. Najbauer József
- 25. Immunity against tumors. - Dr. Németh Péter János
- 26. Immunological aspects of organ transplantation. - Dr. Németh Péter János
- 27. Immuno-based therapies. - Dr. Németh Péter János
- 28. Protein therapies. Recombinant cytokines. Vaccine development. - Dr. Najbauer József
Gyakorlatok
- 1. Introduction, structure of lymphoid organs.
- 2. Introduction, structure of lymphoid organs.
- 3. Immune defense against viruses, bacteria and fungi, diagnostic possibilities.
- 4. Immune defense against viruses, bacteria and fungi, diagnostic possibilities.
- 5. Vaccines.
- 6. Vaccines.
- 7. Autoantibody diagnostics
- 8. Autoantibody diagnostics
- 9. HLA typing.
- 10. HLA typing.
- 11. Consultation.
- 12. Consultation.
- 13. Cells of the immune system, CD markers.
- 14. Cells of the immune system, CD markers.
- 15. Development of poly- and monoclonal antibodies and their applications. Immunization. Antibody production (fermentation), purification, labelling. Hybridoma technique.
- 16. Development of poly- and monoclonal antibodies and their applications. Immunization. Antibody production (fermentation), purification, labelling. Hybridoma technique.
- 17. Immunocytochenistry, immunohistochemistry. Fluorescent microscopy.
- 18. Immunocytochenistry, immunohistochemistry. Fluorescent microscopy.
- 19. Flow cytometry. CD marker analysis. Isolation of white blood cells.
- 20. Flow cytometry. CD marker analysis. Isolation of white blood cells.
- 21. Immunserology I.-II. Immunprecipitation, immundiffusion, immunELFO, agglutination, haemagglutination, Coombs-test.
- 22. Immunserology I.-II. Immunprecipitation, immundiffusion, immunELFO, agglutination, haemagglutination, Coombs-test.
- 23. Seminar
- 24. Seminar
- 25. Immunserology III. ELISA, Dot-blot, Western-blot.
- 26. Immunserology III. ELISA, Dot-blot, Western-blot.
- 27. Functional immunological tests: short term tissue cultures. Phagocytosis test. Cytotoxicity test. Lyphocyte activation, cytokine measurements.
- 28. Functional immunological tests: short term tissue cultures. Phagocytosis test. Cytotoxicity test. Lyphocyte activation, cytokine measurements.
Szemináriumok
A tananyag elsajátításához szükséges segédanyagok
Kötelező irodalom
Saját oktatási anyag
See on website www.immbio.hu
Jegyzet
Ajánlott irodalom
Abul K. Abbas: Cellular and Molecular Immunology
Janis Kuby: Immunology
Jan Klein: Immunology
A félév elfogadásának feltételei
Prepared attendance on lectures and practices. No more absence as 3 in practices and lectures. Minimum 10 points in the tests during seminars/laboratory practices or online. The active attendance is controlled by online tests.
Félévközi ellenőrzések
One chance to make up a small test during the practices.
Távolmaradás pótlásának lehetőségei
Practice performed with another group on the same week.
Vizsgakérdések
See on web site www.immbio.hu. The written exam test might contain minimum requirement questions where the wrong answers could mean failure on the exam.
Vizsgáztatók
- Dr. Balogh Péter
- Dr. Berki Timea
- Dr. Boldizsár Ferenc
- Dr. Németh Péter János
Gyakorlatok, szemináriumok oktatói
- Dr. Balogh Péter
- Dr. Berki Timea
- Dr. Boldizsár Ferenc
- Dr. Engelmann Péter András
- Dr. Kellermayer Zoltán
- Dr. Németh Péter János
- Dr. Olasz Katalin Eszter
- Dr. Simon Diána