Immunological Basis of Rheumatoid Arthritis (RA)

Adatok

A Tantárgybejelentőben megadott hivatalos adatok az alábbi tanévre: 2024-2025

Tematika

The aim of the course is to introduce the participants with the immunopathological background of rheumatoid arthritis (RA), paying special attention to the potential molecular and cellular mechanisms, beginning from the clinical features. The topics cover the role of T- and B cells, and cytokine regulation in detail. The role of new T cell groups (regulatory T cells and NKT cells) in the pathogenesis of RA will be discussed. Broadening of the "classical cytokine paradigm" (Th1/Th2): "new" cytokines (IL-17, IL-21, IL-23 and IL-27) and their potential role in RA. Complex, side-by-side discussion of experimental data from human RA patients and RA animal models is a central scope of the course. Getting acquainted with the immunological aspects of RA in detail will help the participants in the understanding of modern therapeutical approaches.

Előadások

Gyakorlatok

Szemináriumok

• 1. Introduction, the aim of the course, requirements. - Boldizsár Ferenc
• 2.

  Natural and pathologic autoantibodies in the blood of healthy and autoimmune patients, the "immunological homunculus"

  .

  - Németh Péter János
• 3. Clinical features of RA (ethiology, diagnosis, symptoms). - Boldizsár Ferenc
• 4. Cells in the pathomechanism of RA 1. T cells. - Boldizsár Ferenc
• 5. Cells in the pathomechanism of RA 2. B cells. - Boldizsár Ferenc
• 6. Cells in the pathomechanism of RA 3. Regulatory T cells. - Boldizsár Ferenc
• 7. Cells in the pathomechanism of RA 4. NKT cells. - Engelmann Péter András
• 8. Cytokine regulators of RA 1. The classical Th1/Th2 paradigm. - Boldizsár Ferenc
• 9. Cytokine regulators of RA 1. IL-17 and other "novel" cytokines (IL-21, IL-23, IL-27). - Boldizsár Ferenc
• 10. Animal models of RA 2. Induced models (proteoglycan-, collagen-, adjuvant-induced arthritis). - Boldizsár Ferenc
• 11. Animal models of RA 3. Spontaneous models. (IL-1R antagonist knock-out-, SKG mice) - Boldizsár Ferenc
• 12. Modern therapeutical approaches of RA. - Boldizsár Ferenc

A tananyag elsajátításához szükséges segédanyagok

Kötelező irodalom

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Saját oktatási anyag

The slides of the seminars will be available on-line on the website of the Department of Immunology and Biotechnology (www.immbio.hu).

Jegyzet

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Ajánlott irodalom

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A félév elfogadásának feltételei

Maximum number of absences: 2. Participants will prepare a short talk based on a paper selected by the tutor and related to one of the topics of the seminars.

Félévközi ellenőrzések

None.

Távolmaradás pótlásának lehetőségei

None.

Vizsgakérdések

None.

Vizsgáztatók

Gyakorlatok, szemináriumok oktatói

• Boldizsár Ferenc
• Engelmann Péter András
• Németh Péter János